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Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk.

Publication ,  Journal Article
Muskens, IS; Hansen, HM; Smirnov, IV; Molinaro, AM; Bondy, ML; Schildkraut, JM; Wrensch, M; Wiemels, JL; Claus, EB
Published in: J Neurooncol
May 2019

PURPOSE: Telomere length-associated SNPs have been associated with incidence and survival rates for malignant brain tumors such as glioma. Here, we study the influence of genetically determined lymphocyte telomere length (LTL) by comparing telomerase associated SNPs between the most common non-malignant brain tumor, i.e. meningioma, and healthy controls. METHODS/PATIENTS: One thousand fifty-three (1053) surgically treated meningioma patients and 4437 controls of Western European ancestry were included. Germline DNA was genotyped for 8 SNPs previously significantly associated with LTL. Genotypically-estimated LTL was then calculated by summing each SNP's genotypically-specified telomere length increase in base pairs (bp) for each person. Odds ratios for genotypically-estimated LTL in meningioma cases and controls were evaluated using logistic regression with the first two ancestral principal components and sex as covariates. RESULTS: Three out of the eight evaluated LTL SNPs were significantly associated with increased meningioma risk (rs10936599: OR 1.14, 95% CI 1.01-1.28, rs2736100: OR 1.13, 95% CI 1.03-1.25, rs9420907: OR 1.22, 95% CI 1.07-1.39). Only rs9420907 remained significant after correction for multiple testing. Average genotypically-estimated LTL was significantly longer for those with meningioma compared to controls [mean cases: 560.2 bp (standard error (SE): 4.05 bp), mean controls: 541.5 bp (SE: 2.02 bp), logistic regression p value = 2.13 × 10-5]. CONCLUSION: Increased genotypically-estimated LTL was significantly associated with increased meningioma risk. A role for telomere length in the pathophysiology of meningioma is novel, and could lead to new insights on the etiology of meningioma.

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Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

May 2019

Volume

142

Issue

3

Start / End Page

479 / 487

Location

United States

Related Subject Headings

  • Telomere Homeostasis
  • Risk Factors
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Meningioma
  • Meningeal Neoplasms
  • Male
  • Leukocytes
  • Humans
 

Citation

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MLA
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Muskens, I. S., Hansen, H. M., Smirnov, I. V., Molinaro, A. M., Bondy, M. L., Schildkraut, J. M., … Claus, E. B. (2019). Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk. J Neurooncol, 142(3), 479–487. https://doi.org/10.1007/s11060-019-03119-w
Muskens, Ivo S., Helen M. Hansen, Ivan V. Smirnov, Annette M. Molinaro, Melissa L. Bondy, Joellen M. Schildkraut, Margaret Wrensch, Joseph L. Wiemels, and Elizabeth B. Claus. “Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk.J Neurooncol 142, no. 3 (May 2019): 479–87. https://doi.org/10.1007/s11060-019-03119-w.
Muskens IS, Hansen HM, Smirnov IV, Molinaro AM, Bondy ML, Schildkraut JM, et al. Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk. J Neurooncol. 2019 May;142(3):479–87.
Muskens, Ivo S., et al. “Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk.J Neurooncol, vol. 142, no. 3, May 2019, pp. 479–87. Pubmed, doi:10.1007/s11060-019-03119-w.
Muskens IS, Hansen HM, Smirnov IV, Molinaro AM, Bondy ML, Schildkraut JM, Wrensch M, Wiemels JL, Claus EB. Longer genotypically-estimated leukocyte telomere length is associated with increased meningioma risk. J Neurooncol. 2019 May;142(3):479–487.
Journal cover image

Published In

J Neurooncol

DOI

EISSN

1573-7373

Publication Date

May 2019

Volume

142

Issue

3

Start / End Page

479 / 487

Location

United States

Related Subject Headings

  • Telomere Homeostasis
  • Risk Factors
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Meningioma
  • Meningeal Neoplasms
  • Male
  • Leukocytes
  • Humans