CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma.

Journal Article (Letter)

Pilocytic astrocytomas are typically grade I astrocytomas, only rarely progressing to anaplastic counterparts [1]. In the case of anaplastic pilocytic astrocytomas, some are associated with neurofibromatosis type 1 (NF1) [2], others are associated with radiation treatment [2], and the remainder appear de novo. These de novo tumours can be particularly challenging to distinguish from glioblastomas, which are grade IV and carry a worse prognosis. Here we report an unusual case of malignant transformation of a pilocytic astrocytoma in the absence of NF1 alterations or radiation treatment.

Full Text

Duke Authors

Cited Authors

  • López, GY; Perry, A; Harding, B; Li, M; Santi, M

Published Date

  • February 2019

Published In

Volume / Issue

  • 45 / 2

Start / End Page

  • 174 - 178

PubMed ID

  • 29804288

Pubmed Central ID

  • PMC6258357

Electronic International Standard Serial Number (EISSN)

  • 1365-2990

Digital Object Identifier (DOI)

  • 10.1111/nan.12503


  • eng

Conference Location

  • England