Role of free radicals in alcohol-induced tissue injury


Book Section

© 1997 Taylor & Francis. All rights reserved. The role of reactive oxygen intermediates (ROI) and reactive nitrogen intermediates (RNI) in ethanol-induced toxicity has been supported by a variety of in vivo and in vitro studies. All tissues in the body are affected by exposure to ethanol, and variations in the toxic effects may be a reflection of the ROI/RNI generating mechanisms available in that tissue as well as the level of antioxidant protection. To understand how ethanol alters the redox balance of a cell, it is important to briefly review the basic mechanisms underlying ROI and RNI generation, the types of reactions that these molecules can undergo, and the protective or reaction-terminating mechanisms that are available to prevent oxidative damage.

Full Text

Duke Authors

Cited Authors

  • Colton, C; Zakhari, S

Published Date

  • January 1, 2017

Book Title

  • Oxidants, Antioxidants, and Free Radicals

Start / End Page

  • 259 - 272

International Standard Book Number 10 (ISBN-10)

  • 1560326441

International Standard Book Number 13 (ISBN-13)

  • 9781560326441

Digital Object Identifier (DOI)

  • 10.1201/9780203744673

Citation Source

  • Scopus