Periocular Histiocytoid Carcinoma: Potential Diagnostic Challenges.

Journal Article (Journal Article)

Cutaneous histiocytoid carcinoma can occur as a primary tumor of the periocular region. Morphologically similar histiocytoid carcinomas arising as primary tumors of the breast have a predilection for orbital metastases. They can occasionally contain regions with prominent vacuolated cytoplasm and minimal nuclear atypia, which mimic benign histiocytic lesions. Differentiating nonneoplastic, primary neoplastic, and metastatic histiocytoid lesions involving the periorbita can be challenging for both the clinician and the pathologist, and this distinction has management implications. Herein, we present 3 cases to illustrate the challenges of diagnosing periocular histiocytoid carcinoma.

Full Text

Duke Authors

Cited Authors

  • Yates, JR; Mines, MJ; Subramanian, PS; Rivera-Michlig, R; Cummings, TJ; Eberhart, CG

Published Date

  • February 2019

Published In

Volume / Issue

  • 5 / 2

Start / End Page

  • 94 - 101

PubMed ID

  • 30976586

Pubmed Central ID

  • PMC6422134

International Standard Serial Number (ISSN)

  • 2296-4681

Digital Object Identifier (DOI)

  • 10.1159/000490250


  • eng

Conference Location

  • Switzerland