Apical constriction: a cell shape change that can drive morphogenesis.

Published

Journal Article (Review)

Biologists have long recognized that dramatic bending of a cell sheet may be driven by even modest shrinking of the apical sides of cells. Cell shape changes and tissue movements like these are at the core of many of the morphogenetic movements that shape animal form during development, driving processes such as gastrulation, tube formation, and neurulation. The mechanisms of such cell shape changes must integrate developmental patterning information in order to spatially and temporally control force production-issues that touch on fundamental aspects of both cell and developmental biology and on birth defects research. How does developmental patterning regulate force-producing mechanisms, and what roles do such mechanisms play in development? Work on apical constriction from multiple systems including Drosophila, Caenorhabditis elegans, sea urchin, Xenopus, chick, and mouse has begun to illuminate these issues. Here, we review this effort to explore the diversity of mechanisms of apical constriction, the diversity of roles that apical constriction plays in development, and the common themes that emerge from comparing systems.

Full Text

Duke Authors

Cited Authors

  • Sawyer, JM; Harrell, JR; Shemer, G; Sullivan-Brown, J; Roh-Johnson, M; Goldstein, B

Published Date

  • May 1, 2010

Published In

Volume / Issue

  • 341 / 1

Start / End Page

  • 5 - 19

PubMed ID

  • 19751720

Pubmed Central ID

  • 19751720

Electronic International Standard Serial Number (EISSN)

  • 1095-564X

Digital Object Identifier (DOI)

  • 10.1016/j.ydbio.2009.09.009

Language

  • eng

Conference Location

  • United States