Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory.

Journal Article (Journal Article)

Episodic memory retrieval relies on the recovery of neural representations of waking experience. This process is thought to involve a communication dynamic between the medial temporal lobe memory system and the neocortex. How this occurs is largely unknown, however, especially as it pertains to awake human memory retrieval. Using intracranial electroencephalographic recordings, we found that ripple oscillations were dynamically coupled between the human medial temporal lobe (MTL) and temporal association cortex. Coupled ripples were more pronounced during successful verbal memory retrieval and recover the cortical neural representations of remembered items. Together, these data provide direct evidence that coupled ripples between the MTL and association cortex may underlie successful memory retrieval in the human brain.

Full Text

Duke Authors

Cited Authors

  • Vaz, AP; Inati, SK; Brunel, N; Zaghloul, KA

Published Date

  • March 1, 2019

Published In

Volume / Issue

  • 363 / 6430

Start / End Page

  • 975 - 978

PubMed ID

  • 30819961

Pubmed Central ID

  • PMC6478623

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.aau8956


  • eng

Conference Location

  • United States