An alpha hydroxy acid derivative suitable for sensitive skin.

Journal Article (Journal Article)

BACKGROUND: Individuals with sensitive skin may not tolerate some products formulated with alpha hydroxy acids (AHAs) due to unacceptable levels of stinging and irritation. OBJECTIVE: To develop a neutral molecule that is well tolerated by individuals with sensitive skin without stinging or irritation, yet retains the beneficial effects of AHAs. METHODS: A neutral amide derivative, methoxypropylgluconamide (MPG), was invented. Formulations containing MPG (15%) were tested by cummulative irritation, repeat insult patch testing, and lactic acid stinging assay. Bilateral comparison clinical and histological studies of xerosis and photoaging assessments were performed. RESULTS: MPG was nonirritating and nonsensitizing. Clinically significant improvements in xerosis and photoaging including uneven pigmentation were seen. Improvement in the morphology of the stratum corneum epidermis and in the amount of glycosaminoglycans in the epidermis and dermis were seen histologically. CONCLUSIONS: A molecule was invented (MPG) that could be formulated in a neutral vehicle to avoid skin irritation and produced improvements in xerosis and photoaging.

Full Text

Duke Authors

Cited Authors

  • Wolf, BA; Paster, A; Levy, SB

Published Date

  • May 1996

Published In

Volume / Issue

  • 22 / 5

Start / End Page

  • 469 - 473

PubMed ID

  • 8634811

International Standard Serial Number (ISSN)

  • 1076-0512

Digital Object Identifier (DOI)

  • 10.1111/j.1524-4725.1996.tb00349.x


  • eng

Conference Location

  • United States