Human antibody response to Anopheles gambiae saliva: an immuno-epidemiological biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control.

Published

Journal Article

For the fight against malaria, the World Health Organization (WHO) has emphasized the need for indicators to evaluate the efficacy of vector-control strategies. This study investigates a potential immunological marker, based on human antibody responses to Anopheles saliva, as a new indicator to evaluate the efficacy of insecticide-treated nets (ITNs). Parasitological, entomological, and immunological assessments were carried out in children and adults from a malaria-endemic region of Angola before and after the introduction of ITNs. Immunoglobulin G (IgG) levels to An. gambiae saliva were positively associated with the intensity of An. gambiae exposure and malaria infection. A significant decrease in the anti-saliva IgG response was observed after the introduction of ITNs, and this was associated with a drop in parasite load. This study represents the first stage in the development of a new indicator to evaluate the efficacy of malaria vector-control strategies, which could apply in other arthropod vector-borne diseases.

Full Text

Duke Authors

Cited Authors

  • Drame, PM; Poinsignon, A; Besnard, P; Le Mire, J; Dos-Santos, MA; Sow, CS; Cornelie, S; Foumane, V; Toto, J-C; Sembene, M; Boulanger, D; Simondon, F; Fortes, F; Carnevale, P; Remoue, F

Published Date

  • July 2010

Published In

Volume / Issue

  • 83 / 1

Start / End Page

  • 115 - 121

PubMed ID

  • 20595489

Pubmed Central ID

  • 20595489

Electronic International Standard Serial Number (EISSN)

  • 1476-1645

International Standard Serial Number (ISSN)

  • 0002-9637

Digital Object Identifier (DOI)

  • 10.4269/ajtmh.2010.09-0684

Language

  • eng