Human antibody response to Anopheles gambiae saliva: an immuno-epidemiological biomarker to evaluate the efficacy of insecticide-treated nets in malaria vector control.


Journal Article

For the fight against malaria, the World Health Organization (WHO) has emphasized the need for indicators to evaluate the efficacy of vector-control strategies. This study investigates a potential immunological marker, based on human antibody responses to Anopheles saliva, as a new indicator to evaluate the efficacy of insecticide-treated nets (ITNs). Parasitological, entomological, and immunological assessments were carried out in children and adults from a malaria-endemic region of Angola before and after the introduction of ITNs. Immunoglobulin G (IgG) levels to An. gambiae saliva were positively associated with the intensity of An. gambiae exposure and malaria infection. A significant decrease in the anti-saliva IgG response was observed after the introduction of ITNs, and this was associated with a drop in parasite load. This study represents the first stage in the development of a new indicator to evaluate the efficacy of malaria vector-control strategies, which could apply in other arthropod vector-borne diseases.

Full Text

Duke Authors

Cited Authors

  • Drame, PM; Poinsignon, A; Besnard, P; Le Mire, J; Dos-Santos, MA; Sow, CS; Cornelie, S; Foumane, V; Toto, J-C; Sembene, M; Boulanger, D; Simondon, F; Fortes, F; Carnevale, P; Remoue, F

Published Date

  • July 2010

Published In

Volume / Issue

  • 83 / 1

Start / End Page

  • 115 - 121

PubMed ID

  • 20595489

Pubmed Central ID

  • 20595489

Electronic International Standard Serial Number (EISSN)

  • 1476-1645

International Standard Serial Number (ISSN)

  • 0002-9637

Digital Object Identifier (DOI)

  • 10.4269/ajtmh.2010.09-0684


  • eng