Spotlight on zebrafish: the next wave of translational research.

Journal Article (Editorial)

Five years after the launch of the Disease Models & Mechanisms (DMM) Special Issue on zebrafish as a disease model, the field has progressed significantly. Zebrafish have been used to precisely model human genetic variants, to unpick the mechanisms of metabolic and other diseases, to study infection, inflammation and cancer, and to develop and test new therapeutic approaches. In this Editorial, we highlight recent research published in DMM that uses zebrafish to develop new experimental tools and to provide new insight into disease mechanism and therapy. The broad spectrum of subjects and approaches covered in these articles underscores the versatility of zebrafish in translational research. Further, it highlights the zebrafish community's ethos of creativity and collaboration in translating basic biological research into clinically relevant advances affecting how we understand and treat human disease.

Full Text

Duke Authors

Cited Authors

  • Patton, EE; Tobin, DM

Published Date

  • March 7, 2019

Published In

Volume / Issue

  • 12 / 3

PubMed ID

  • 30858282

Pubmed Central ID

  • PMC6451428

Electronic International Standard Serial Number (EISSN)

  • 1754-8411

Digital Object Identifier (DOI)

  • 10.1242/dmm.039370


  • eng

Conference Location

  • England