Neural crest-derived neurons invade the ovary but not the testis during mouse gonad development.

Published

Journal Article

Testes and ovaries undergo sex-specific morphogenetic changes and adopt strikingly different morphologies, despite the fact that both arise from a common precursor, the bipotential gonad. Previous studies showed that recruitment of vasculature is critical for testis patterning. However, vasculature is not recruited into the early ovary. Peripheral innervation is involved in patterning development of many organs but has been given little attention in gonad development. In this study, we show that while innervation in the male reproductive complex is restricted to the epididymis and vas deferens and never invades the interior of the testis, neural crest-derived innervation invades the interior of the ovary around E16.5. Individual neural crest cells colonize the ovary, differentiate into neurons and glia, and form a dense neural network within the ovarian medulla. Using a sex-reversing mutant mouse line, we show that innervation is specific to ovary development, is not dependent on the genetic sex of gonadal or neural crest cells, and may be blocked by repressive guidance signals elevated in the male pathway. This study reveals another aspect of sexually dimorphic gonad development, establishes a precise timeline and structure of ovarian innervation, and raises many questions for future research.

Full Text

Duke Authors

Cited Authors

  • McKey, J; Bunce, C; Batchvarov, IS; Ornitz, DM; Capel, B

Published Date

  • March 19, 2019

Published In

Volume / Issue

  • 116 / 12

Start / End Page

  • 5570 - 5575

PubMed ID

  • 30819894

Pubmed Central ID

  • 30819894

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

Digital Object Identifier (DOI)

  • 10.1073/pnas.1814930116

Language

  • eng

Conference Location

  • United States