Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp.

Published

Journal Article

In the course of our studies of coprophilous fungi as sources of antifungal agents, a strain of an undescribed species in the genus Niesslia (TTI-0426) was isolated from horse dung collected in Texas. An extract from fermentation cultures of this strain afforded two new antifungal wortmannin derivatives, wortmannins C and D (1 and 2), as well as four additional new related compounds, wortmannines B1-B4 (3-6), containing an unusual ring system. The structures of these metabolites were established mainly by analysis of HRESIMS and 2D NMR data. Relative configurations were assigned using NOESY data, and the structure assignments were supported by NMR comparison with similar compounds. Wortmannins C and D showed activity against Cryptococcus neoformans and Candida albicans in disk assays, but low MIC potency observed for 1 was suggested to be due in part to efflux processes on the basis of assay results for a Schizosaccharomyces pombe efflux mutant in comparison to wild-type.

Full Text

Duke Authors

Cited Authors

  • Dischler, NM; Xu, L; Li, Y; Nichols, CB; Alspaugh, JA; Bills, GF; Gloer, JB

Published Date

  • March 22, 2019

Published In

Volume / Issue

  • 82 / 3

Start / End Page

  • 532 - 538

PubMed ID

  • 30844268

Pubmed Central ID

  • 30844268

Electronic International Standard Serial Number (EISSN)

  • 1520-6025

Digital Object Identifier (DOI)

  • 10.1021/acs.jnatprod.8b00923

Language

  • eng

Conference Location

  • United States