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Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp.

Publication ,  Journal Article
Dischler, NM; Xu, L; Li, Y; Nichols, CB; Alspaugh, JA; Bills, GF; Gloer, JB
Published in: J Nat Prod
March 22, 2019
Published version (DOI) Link to item

In the course of our studies of coprophilous fungi as sources of antifungal agents, a strain of an undescribed species in the genus Niesslia (TTI-0426) was isolated from horse dung collected in Texas. An extract from fermentation cultures of this strain afforded two new antifungal wortmannin derivatives, wortmannins C and D (1 and 2), as well as four additional new related compounds, wortmannines B1-B4 (3-6), containing an unusual ring system. The structures of these metabolites were established mainly by analysis of HRESIMS and 2D NMR data. Relative configurations were assigned using NOESY data, and the structure assignments were supported by NMR comparison with similar compounds. Wortmannins C and D showed activity against Cryptococcus neoformans and Candida albicans in disk assays, but low MIC potency observed for 1 was suggested to be due in part to efflux processes on the basis of assay results for a Schizosaccharomyces pombe efflux mutant in comparison to wild-type.

Duke Scholars

James Andrew Alspaugh II
Author James Andrew Alspaugh II Medicine, Infectious Diseases

Published In

J Nat Prod

DOI

10.1021/acs.jnatprod.8b00923

EISSN

1520-6025

Publication Date

March 22, 2019

Volume

82

Issue

3

Start / End Page

532 / 538

Location

United States

Related Subject Headings

  • Wortmannin
  • Spectrum Analysis
  • Schizosaccharomyces
  • Molecular Structure
  • Microbial Sensitivity Tests
  • Medicinal & Biomolecular Chemistry
  • Hypocreales
  • Fermentation
  • Cryptococcus neoformans
  • Candida albicans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dischler, N. M., Xu, L., Li, Y., Nichols, C. B., Alspaugh, J. A., Bills, G. F., & Gloer, J. B. (2019). Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp. J Nat Prod, 82(3), 532–538. https://doi.org/10.1021/acs.jnatprod.8b00923
Dischler, Nicole M., Lijian Xu, Yan Li, Connie B. Nichols, J Andrew Alspaugh, Gerald F. Bills, and James B. Gloer. “Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp.” J Nat Prod 82, no. 3 (March 22, 2019): 532–38. https://doi.org/10.1021/acs.jnatprod.8b00923.
Dischler NM, Xu L, Li Y, Nichols CB, Alspaugh JA, Bills GF, et al. Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp. J Nat Prod. 2019 Mar 22;82(3):532–8.
Dischler, Nicole M., et al. “Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp.” J Nat Prod, vol. 82, no. 3, Mar. 2019, pp. 532–38. Pubmed, doi:10.1021/acs.jnatprod.8b00923.
Dischler NM, Xu L, Li Y, Nichols CB, Alspaugh JA, Bills GF, Gloer JB. Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp. J Nat Prod. 2019 Mar 22;82(3):532–538.
Journal cover image

Published In

J Nat Prod

DOI

10.1021/acs.jnatprod.8b00923

EISSN

1520-6025

Publication Date

March 22, 2019

Volume

82

Issue

3

Start / End Page

532 / 538

Location

United States

Related Subject Headings

  • Wortmannin
  • Spectrum Analysis
  • Schizosaccharomyces
  • Molecular Structure
  • Microbial Sensitivity Tests
  • Medicinal & Biomolecular Chemistry
  • Hypocreales
  • Fermentation
  • Cryptococcus neoformans
  • Candida albicans