Perioperative Quality Initiative consensus statement on intraoperative blood pressure, risk and outcomes for elective surgery.

Published

Journal Article

BACKGROUND: Intraoperative mortality is now rare, but death within 30 days of surgery remains surprisingly common. Perioperative myocardial infarction is associated with a remarkably high mortality. There are strong associations between hypotension and myocardial injury, myocardial infarction, renal injury, and death. Perioperative arterial blood pressure management was thus the basis of a Perioperative Quality Initiative consensus-building conference held in London in July 2017. METHODS: The meeting featured a modified Delphi process in which groups addressed various aspects of perioperative arterial pressure. RESULTS: Three consensus statements on intraoperative blood pressure were established. 1) Intraoperative mean arterial pressures below 60-70 mm Hg are associated with myocardial injury, acute kidney injury, and death. Injury is a function of hypotension severity and duration. 2) For adult non-cardiac surgical patients, there is insufficient evidence to recommend a general upper limit of arterial pressure at which therapy should be initiated, although pressures above 160 mm Hg have been associated with myocardial injury and infarction. 3) During cardiac surgery, intraoperative systolic arterial pressure above 140 mm Hg is associated with increased 30 day mortality. Injury is a function of arterial pressure severity and duration. CONCLUSIONS: There is increasing evidence that even brief durations of systolic arterial pressure <100 mm Hg and mean arterial pressure <60-70 mm Hg are harmful during non-cardiac surgery.

Full Text

Duke Authors

Cited Authors

  • Sessler, DI; Bloomstone, JA; Aronson, S; Berry, C; Gan, TJ; Kellum, JA; Plumb, J; Mythen, MG; Grocott, MPW; Edwards, MR; Miller, TE; Perioperative Quality Initiative-3 workgroup, ; POQI chairs, ; Grocott, MP; Physiology group, ; Preoperative blood pressure group, ; Intraoperative blood pressure group, ; Postoperative blood pressure group,

Published Date

  • May 2019

Published In

Volume / Issue

  • 122 / 5

Start / End Page

  • 563 - 574

PubMed ID

  • 30916004

Pubmed Central ID

  • 30916004

Electronic International Standard Serial Number (EISSN)

  • 1471-6771

Digital Object Identifier (DOI)

  • 10.1016/j.bja.2019.01.013

Language

  • eng

Conference Location

  • England