Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice.

Journal Article (Journal Article)

As discussion of stress and stress-related disorders rapidly extends beyond the brain, gut microbiota have emerged as a promising contributor to individual differences in the risk of illness, disease course, and treatment response. Here, we employed chronic mild social defeat stress and 16S rRNA gene metagenomic sequencing to investigate the role of microbial composition in mediating anxiety- and depressive-like behavior. In socially defeated animals, we found significant reductions in the overall diversity and relative abundances of numerous bacterial genera, including Akkermansia spp., that positively correlated with behavioral metrics of both anxiety and depression. Functional analyses predicted a reduced frequency of signaling molecule pathways, including G-protein-coupled receptors, in defeated animals. Collectively, our data suggest that shifts in microbial composition may play a role in the pathogenesis of anxiety and depression.

Full Text

Duke Authors

Cited Authors

  • McGaughey, KD; Yilmaz-Swenson, T; Elsayed, NM; Cruz, DA; Rodriguiz, RM; Kritzer, MD; Peterchev, AV; Roach, J; Wetsel, WC; Williamson, DE

Published Date

  • March 1, 2019

Published In

Volume / Issue

  • 9 / 1

Start / End Page

  • 3281 -

PubMed ID

  • 30824791

Pubmed Central ID

  • PMC6397238

Electronic International Standard Serial Number (EISSN)

  • 2045-2322

Digital Object Identifier (DOI)

  • 10.1038/s41598-019-40140-5


  • eng

Conference Location

  • England