Beyond pharmacological treatment: an insight into therapies that target specific aspects of heart failure pathophysiology.
Journal Article (Journal Article;Review)
Heart failure is a common syndrome associated with substantial morbidity and mortality. The management of symptoms and the strategies for improving prognosis have largely been based on pharmacological treatments. The pathophysiology of heart failure is complex because of the multiple causes responsible for this syndrome. This Series paper presents some examples of advances in heart failure management, in which the treatment specifically targets the underlying pathophysiological mechanisms responsible for the symptoms. These treatments include treatment of electromechanical dyssynchrony and dysrhythmia by cardiac resynchronisation and implantable cardioverter-defibrillators; neurohumoral modification by baroreflex and vagal stimulation; prevention of adverse cardiac remodelling by interatrial shunts; and finally targeting the myocardium directly by cell therapy in an attempt to regenerate new myocardial cells.
Full Text
Duke Authors
Cited Authors
- Normand, C; Kaye, DM; Povsic, TJ; Dickstein, K
Published Date
- March 9, 2019
Published In
Volume / Issue
- 393 / 10175
Start / End Page
- 1045 - 1055
PubMed ID
- 30860030
Electronic International Standard Serial Number (EISSN)
- 1474-547X
Digital Object Identifier (DOI)
- 10.1016/S0140-6736(18)32216-5
Language
- eng
Conference Location
- England