Beyond pharmacological treatment: an insight into therapies that target specific aspects of heart failure pathophysiology.

Journal Article (Journal Article;Review)

Heart failure is a common syndrome associated with substantial morbidity and mortality. The management of symptoms and the strategies for improving prognosis have largely been based on pharmacological treatments. The pathophysiology of heart failure is complex because of the multiple causes responsible for this syndrome. This Series paper presents some examples of advances in heart failure management, in which the treatment specifically targets the underlying pathophysiological mechanisms responsible for the symptoms. These treatments include treatment of electromechanical dyssynchrony and dysrhythmia by cardiac resynchronisation and implantable cardioverter-defibrillators; neurohumoral modification by baroreflex and vagal stimulation; prevention of adverse cardiac remodelling by interatrial shunts; and finally targeting the myocardium directly by cell therapy in an attempt to regenerate new myocardial cells.

Full Text

Duke Authors

Cited Authors

  • Normand, C; Kaye, DM; Povsic, TJ; Dickstein, K

Published Date

  • March 9, 2019

Published In

Volume / Issue

  • 393 / 10175

Start / End Page

  • 1045 - 1055

PubMed ID

  • 30860030

Electronic International Standard Serial Number (EISSN)

  • 1474-547X

Digital Object Identifier (DOI)

  • 10.1016/S0140-6736(18)32216-5


  • eng

Conference Location

  • England