Mutations in the cilia gene ARL13B lead to the classical form of Joubert syndrome.


Journal Article

Joubert syndrome (JS) and related disorders are a group of autosomal-recessive conditions sharing the "molar tooth sign" on axial brain MRI, together with cerebellar vermis hypoplasia, ataxia, and psychomotor delay. JS is suggested to be a disorder of cilia function and is part of a spectrum of disorders involving retinal, renal, digital, oral, hepatic, and cerebral organs. We identified mutations in ARL13B in two families with the classical form of JS. ARL13B belongs to the Ras GTPase family, and in other species is required for ciliogenesis, body axis formation, and renal function. The encoded Arl13b protein was expressed in developing murine cerebellum and localized to the cilia in primary neurons. Overexpression of human wild-type but not patient mutant ARL13B rescued the Arl13b scorpion zebrafish mutant. Thus, ARL13B has an evolutionarily conserved role mediating cilia function in multiple organs.

Full Text

Duke Authors

Cited Authors

  • Cantagrel, V; Silhavy, JL; Bielas, SL; Swistun, D; Marsh, SE; Bertrand, JY; Audollent, S; Attié-Bitach, T; Holden, KR; Dobyns, WB; Traver, D; Al-Gazali, L; Ali, BR; Lindner, TH; Caspary, T; Otto, EA; Hildebrandt, F; Glass, IA; Logan, CV; Johnson, CA; Bennett, C; Brancati, F; International Joubert Syndrome Related Disorders Study Group, ; Valente, EM; Woods, CG; Gleeson, JG

Published Date

  • August 2008

Published In

Volume / Issue

  • 83 / 2

Start / End Page

  • 170 - 179

PubMed ID

  • 18674751

Pubmed Central ID

  • 18674751

Electronic International Standard Serial Number (EISSN)

  • 1537-6605

Digital Object Identifier (DOI)

  • 10.1016/j.ajhg.2008.06.023


  • eng

Conference Location

  • United States