Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer.
Altered metabolism is a common feature of new and recurring malignancy. In this issue of Cancer Cell, Reina-Campos and colleagues report upregulation of the serine, glycine, one-carbon (SGOC) metabolic network is required for neuroendocrine prostate cancer, a castration-resistant aggressive form of the disease, and presents a targetable vulnerability.
Gao, X; Locasale, JW; Reid, MA
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