Serine and Methionine Metabolism: Vulnerabilities in Lethal Prostate Cancer.

Journal Article (Journal Article)

Altered metabolism is a common feature of new and recurring malignancy. In this issue of Cancer Cell, Reina-Campos and colleagues report upregulation of the serine, glycine, one-carbon (SGOC) metabolic network is required for neuroendocrine prostate cancer, a castration-resistant aggressive form of the disease, and presents a targetable vulnerability.

Full Text

Duke Authors

Cited Authors

  • Gao, X; Locasale, JW; Reid, MA

Published Date

  • March 18, 2019

Published In

Volume / Issue

  • 35 / 3

Start / End Page

  • 339 - 341

PubMed ID

  • 30889375

Pubmed Central ID

  • PMC6425948

Electronic International Standard Serial Number (EISSN)

  • 1878-3686

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2019.02.014


  • eng

Conference Location

  • United States