Revisiting the determinants of the glomerular filtration barrier: what goes round must come round.

Journal Article (Journal Article)

The glomerular filtration barrier (GFB) is characterized by a very high hydraulic permeability, combined with a marked permselectivity that excludes macromolecules such as albumin. Thus, the GFB retains most of the plasma proteins, with only 0.06% of albumin getting across the basement membrane. The GFB consists of 3 layers: fenestrated endothelial cells, the glomerular basement membrane, and podocytes. Injury to any of these components can result in the development of proteinuria. The contribution of the major components of the GFB has recently been reexamined and is discussed in the context of our past and present understanding.

Full Text

Duke Authors

Cited Authors

  • Schlöndorff, D; Wyatt, CM; Campbell, KN

Published Date

  • September 2017

Published In

Volume / Issue

  • 92 / 3

Start / End Page

  • 533 - 536

PubMed ID

  • 28807257

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1016/j.kint.2017.06.003


  • eng

Conference Location

  • United States