Revisiting the determinants of the glomerular filtration barrier: what goes round must come round.
Publication
, Journal Article
Schlöndorff, D; Wyatt, CM; Campbell, KN
Published in: Kidney Int
September 2017
The glomerular filtration barrier (GFB) is characterized by a very high hydraulic permeability, combined with a marked permselectivity that excludes macromolecules such as albumin. Thus, the GFB retains most of the plasma proteins, with only 0.06% of albumin getting across the basement membrane. The GFB consists of 3 layers: fenestrated endothelial cells, the glomerular basement membrane, and podocytes. Injury to any of these components can result in the development of proteinuria. The contribution of the major components of the GFB has recently been reexamined and is discussed in the context of our past and present understanding.
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Published In
Kidney Int
DOI
EISSN
1523-1755
Publication Date
September 2017
Volume
92
Issue
3
Start / End Page
533 / 536
Location
United States
Related Subject Headings
- Urology & Nephrology
- Proteinuria
- Podocytes
- Kidney Glomerulus
- Humans
- Glomerular Filtration Barrier
- Glomerular Basement Membrane
- Endothelial Cells
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Schlöndorff, D., Wyatt, C. M., & Campbell, K. N. (2017). Revisiting the determinants of the glomerular filtration barrier: what goes round must come round. Kidney Int, 92(3), 533–536. https://doi.org/10.1016/j.kint.2017.06.003
Schlöndorff, Detlef, Christina M. Wyatt, and Kirk N. Campbell. “Revisiting the determinants of the glomerular filtration barrier: what goes round must come round.” Kidney Int 92, no. 3 (September 2017): 533–36. https://doi.org/10.1016/j.kint.2017.06.003.
Schlöndorff D, Wyatt CM, Campbell KN. Revisiting the determinants of the glomerular filtration barrier: what goes round must come round. Kidney Int. 2017 Sep;92(3):533–6.
Schlöndorff, Detlef, et al. “Revisiting the determinants of the glomerular filtration barrier: what goes round must come round.” Kidney Int, vol. 92, no. 3, Sept. 2017, pp. 533–36. Pubmed, doi:10.1016/j.kint.2017.06.003.
Schlöndorff D, Wyatt CM, Campbell KN. Revisiting the determinants of the glomerular filtration barrier: what goes round must come round. Kidney Int. 2017 Sep;92(3):533–536.
Published In
Kidney Int
DOI
EISSN
1523-1755
Publication Date
September 2017
Volume
92
Issue
3
Start / End Page
533 / 536
Location
United States
Related Subject Headings
- Urology & Nephrology
- Proteinuria
- Podocytes
- Kidney Glomerulus
- Humans
- Glomerular Filtration Barrier
- Glomerular Basement Membrane
- Endothelial Cells
- 3202 Clinical sciences
- 1103 Clinical Sciences