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Revisiting the determinants of the glomerular filtration barrier: what goes round must come round.

Publication ,  Journal Article
Schlöndorff, D; Wyatt, CM; Campbell, KN
Published in: Kidney Int
September 2017

The glomerular filtration barrier (GFB) is characterized by a very high hydraulic permeability, combined with a marked permselectivity that excludes macromolecules such as albumin. Thus, the GFB retains most of the plasma proteins, with only 0.06% of albumin getting across the basement membrane. The GFB consists of 3 layers: fenestrated endothelial cells, the glomerular basement membrane, and podocytes. Injury to any of these components can result in the development of proteinuria. The contribution of the major components of the GFB has recently been reexamined and is discussed in the context of our past and present understanding.

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Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

September 2017

Volume

92

Issue

3

Start / End Page

533 / 536

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Proteinuria
  • Podocytes
  • Kidney Glomerulus
  • Humans
  • Glomerular Filtration Barrier
  • Glomerular Basement Membrane
  • Endothelial Cells
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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ICMJE
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Schlöndorff, D., Wyatt, C. M., & Campbell, K. N. (2017). Revisiting the determinants of the glomerular filtration barrier: what goes round must come round. Kidney Int, 92(3), 533–536. https://doi.org/10.1016/j.kint.2017.06.003
Schlöndorff, Detlef, Christina M. Wyatt, and Kirk N. Campbell. “Revisiting the determinants of the glomerular filtration barrier: what goes round must come round.Kidney Int 92, no. 3 (September 2017): 533–36. https://doi.org/10.1016/j.kint.2017.06.003.
Schlöndorff D, Wyatt CM, Campbell KN. Revisiting the determinants of the glomerular filtration barrier: what goes round must come round. Kidney Int. 2017 Sep;92(3):533–6.
Schlöndorff, Detlef, et al. “Revisiting the determinants of the glomerular filtration barrier: what goes round must come round.Kidney Int, vol. 92, no. 3, Sept. 2017, pp. 533–36. Pubmed, doi:10.1016/j.kint.2017.06.003.
Schlöndorff D, Wyatt CM, Campbell KN. Revisiting the determinants of the glomerular filtration barrier: what goes round must come round. Kidney Int. 2017 Sep;92(3):533–536.
Journal cover image

Published In

Kidney Int

DOI

EISSN

1523-1755

Publication Date

September 2017

Volume

92

Issue

3

Start / End Page

533 / 536

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Proteinuria
  • Podocytes
  • Kidney Glomerulus
  • Humans
  • Glomerular Filtration Barrier
  • Glomerular Basement Membrane
  • Endothelial Cells
  • 3202 Clinical sciences
  • 1103 Clinical Sciences