Identification of a protective proteomic signature and a potential therapeutic target in diabetic nephropathy.

Journal Article (Journal Article)

In a recent paper in Nature Medicine, Qi et al. set out to identify protective pathways in patients with longstanding diabetes who do not develop diabetic nephropathy. Unbiased proteomic analysis of kidney tissue identified a unique protein signature in unaffected individuals. Studies in vitro and in murine models identified the highly upregulated glycolytic enzyme pyruvate kinase M2 as a potential therapeutic target to prevent or treat diabetic nephropathy.

Full Text

Duke Authors

Cited Authors

  • Chun, N; Wyatt, CM; He, JC

Published Date

  • October 2017

Published In

Volume / Issue

  • 92 / 4

Start / End Page

  • 780 - 781

PubMed ID

  • 28938946

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1016/j.kint.2017.08.002


  • eng

Conference Location

  • United States