In vitro generation of renal tubular epithelial cells from fibroblasts: implications for precision and regenerative medicine in nephrology.

Published

Journal Article

Prior efforts to generate renal epithelial cells in vitro have relied on pluripotent or bone marrow-derived mesenchymal stem cells. A recent publication in Nature Cell Biology describes the generation of induced tubular epithelial cells from fibroblasts, potentially offering a novel platform for personalized drug toxicity screening and in vitro disease modeling. This report serves as a promising proof of principle study and opens future research directions, including the optimization of the reprogramming process, efficient translation to adult human fibroblasts, and the generation of highly specific functional renal cell types.

Full Text

Duke Authors

Cited Authors

  • Wyatt, CM; Dubois, N

Published Date

  • February 2017

Published In

Volume / Issue

  • 91 / 2

Start / End Page

  • 265 - 267

PubMed ID

  • 28087003

Pubmed Central ID

  • 28087003

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1016/j.kint.2016.12.003

Language

  • eng

Conference Location

  • United States