Manipulating the gut microbiome to decrease uremic toxins.

Journal Article (Journal Article)

The uremic solute indoxyl sulfate has been associated with increased mortality and other adverse outcomes in patients with chronic kidney disease. In a recent study published in Cell Host & Microbe, Devlin et al. describe a novel approach to alter the production of indoxyl sulfate through manipulation of the gut microbiota. Although this approach is far from clinical application, it may allow investigators to determine the contribution of uremic solutes to disease pathogenesis.

Full Text

Duke Authors

Cited Authors

  • Yacoub, R; Wyatt, CM

Published Date

  • March 2017

Published In

Volume / Issue

  • 91 / 3

Start / End Page

  • 521 - 523

PubMed ID

  • 28202164

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1016/j.kint.2017.01.003


  • eng

Conference Location

  • United States