Manipulating the gut microbiome to decrease uremic toxins.
Journal Article (Journal Article)
The uremic solute indoxyl sulfate has been associated with increased mortality and other adverse outcomes in patients with chronic kidney disease. In a recent study published in Cell Host & Microbe, Devlin et al. describe a novel approach to alter the production of indoxyl sulfate through manipulation of the gut microbiota. Although this approach is far from clinical application, it may allow investigators to determine the contribution of uremic solutes to disease pathogenesis.
Full Text
Duke Authors
Cited Authors
- Yacoub, R; Wyatt, CM
Published Date
- March 2017
Published In
Volume / Issue
- 91 / 3
Start / End Page
- 521 - 523
PubMed ID
- 28202164
Electronic International Standard Serial Number (EISSN)
- 1523-1755
Digital Object Identifier (DOI)
- 10.1016/j.kint.2017.01.003
Language
- eng
Conference Location
- United States