The sweetest thing: blocking fructose metabolism to prevent acute kidney injury?
Publication
, Journal Article
Wyatt, CM; Reeves, WB
Published in: Kidney Int
May 2017
Fructose consumption has been linked to hypertension in animal models and human studies, and endogenous fructose metabolism has been shown to promote acute and chronic kidney injury in mice. A recent study published in Nature Communications demonstrates a reduction in ischemic acute kidney injury with genetic knockout or inhibition of fructokinase, which catalyzes the first step in fructose metabolism. Although the role of this pathway in human kidney disease remains unclear, the recent description of several candidate fructokinase inhibitors may allow for clinical studies in the future.
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Published In
Kidney Int
DOI
EISSN
1523-1755
Publication Date
May 2017
Volume
91
Issue
5
Start / End Page
998 / 1000
Location
United States
Related Subject Headings
- Urology & Nephrology
- Mice
- Kidney
- Humans
- Fructose
- Animals
- Acute Kidney Injury
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Wyatt, C. M., & Reeves, W. B. (2017). The sweetest thing: blocking fructose metabolism to prevent acute kidney injury? Kidney Int, 91(5), 998–1000. https://doi.org/10.1016/j.kint.2017.03.004
Wyatt, Christina M., and W Brian Reeves. “The sweetest thing: blocking fructose metabolism to prevent acute kidney injury?” Kidney Int 91, no. 5 (May 2017): 998–1000. https://doi.org/10.1016/j.kint.2017.03.004.
Wyatt CM, Reeves WB. The sweetest thing: blocking fructose metabolism to prevent acute kidney injury? Kidney Int. 2017 May;91(5):998–1000.
Wyatt, Christina M., and W. Brian Reeves. “The sweetest thing: blocking fructose metabolism to prevent acute kidney injury?” Kidney Int, vol. 91, no. 5, May 2017, pp. 998–1000. Pubmed, doi:10.1016/j.kint.2017.03.004.
Wyatt CM, Reeves WB. The sweetest thing: blocking fructose metabolism to prevent acute kidney injury? Kidney Int. 2017 May;91(5):998–1000.
Published In
Kidney Int
DOI
EISSN
1523-1755
Publication Date
May 2017
Volume
91
Issue
5
Start / End Page
998 / 1000
Location
United States
Related Subject Headings
- Urology & Nephrology
- Mice
- Kidney
- Humans
- Fructose
- Animals
- Acute Kidney Injury
- 3202 Clinical sciences
- 1103 Clinical Sciences