The sweetest thing: blocking fructose metabolism to prevent acute kidney injury?

Journal Article (Journal Article)

Fructose consumption has been linked to hypertension in animal models and human studies, and endogenous fructose metabolism has been shown to promote acute and chronic kidney injury in mice. A recent study published in Nature Communications demonstrates a reduction in ischemic acute kidney injury with genetic knockout or inhibition of fructokinase, which catalyzes the first step in fructose metabolism. Although the role of this pathway in human kidney disease remains unclear, the recent description of several candidate fructokinase inhibitors may allow for clinical studies in the future.

Full Text

Duke Authors

Cited Authors

  • Wyatt, CM; Reeves, WB

Published Date

  • May 2017

Published In

Volume / Issue

  • 91 / 5

Start / End Page

  • 998 - 1000

PubMed ID

  • 28407885

Pubmed Central ID

  • PMC5546795

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1016/j.kint.2017.03.004


  • eng

Conference Location

  • United States