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Elevated Serum Leptin Levels are Associated With an Increased Risk of Sentinel Lymph Node Metastasis in Cutaneous Melanoma.

Publication ,  Journal Article
Oba, J; Wei, W; Gershenwald, JE; Johnson, MM; Wyatt, CM; Ellerhorst, JA; Grimm, EA
Published in: Medicine (Baltimore)
March 2016

The metabolic hormone leptin has been implicated in the pathogenesis of various malignancies and may contribute to the high rate of cancer in obese individuals. We reported that leptin and its receptor are expressed by melanoma tumors and cell lines, and that leptin stimulates proliferation of cultured melanoma cells. Here, we tested the hypothesis that leptin contributes to early melanoma progression by assessing its association with sentinel node positivity in cutaneous melanoma patients. The study enrolled 72 patients who were scheduled to undergo lymphatic mapping and sentinel node biopsy. Fasting blood was obtained before surgery, and serum leptin levels were measured by enzyme-linked immunosorbent assay (ELISA) with a "raw" (assay value) and an "adjusted" value (raw value divided by body mass index). Leptin levels and other clinicopathologic parameters were compared between sentinel node positive and negative groups. Logistic regression models were used to predict sentinel node status using leptin and other relevant clinical parameters. The raw and adjusted leptin levels were significantly higher in the 15 patients with positive sentinel nodes. These findings could not be attributed to differences in body mass indices. Univariate models revealed raw leptin, adjusted leptin, Breslow thickness, and mitotic rate as significant predictors of sentinel node status. Leptin levels and Breslow thickness remained significant in multivariate models. Survival and follow-up analysis revealed more aggressive disease in diabetic patients. Elevated serum leptin levels predict sentinel node metastasis in melanoma. Validation of this finding in larger cohorts should enable better stratification of early stage melanoma patients.

Duke Scholars

Published In

Medicine (Baltimore)

DOI

EISSN

1536-5964

Publication Date

March 2016

Volume

95

Issue

11

Start / End Page

e3073

Location

United States

Related Subject Headings

  • Texas
  • Skin Neoplasms
  • Sentinel Lymph Node Biopsy
  • Prospective Studies
  • Middle Aged
  • Melanoma
  • Male
  • Lymphatic Metastasis
  • Leptin
  • Humans
 

Citation

APA
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ICMJE
MLA
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Oba, J., Wei, W., Gershenwald, J. E., Johnson, M. M., Wyatt, C. M., Ellerhorst, J. A., & Grimm, E. A. (2016). Elevated Serum Leptin Levels are Associated With an Increased Risk of Sentinel Lymph Node Metastasis in Cutaneous Melanoma. Medicine (Baltimore), 95(11), e3073. https://doi.org/10.1097/MD.0000000000003073
Oba, Junna, Wei Wei, Jeffrey E. Gershenwald, Marcella M. Johnson, Cynthia M. Wyatt, Julie A. Ellerhorst, and Elizabeth A. Grimm. “Elevated Serum Leptin Levels are Associated With an Increased Risk of Sentinel Lymph Node Metastasis in Cutaneous Melanoma.Medicine (Baltimore) 95, no. 11 (March 2016): e3073. https://doi.org/10.1097/MD.0000000000003073.
Oba J, Wei W, Gershenwald JE, Johnson MM, Wyatt CM, Ellerhorst JA, et al. Elevated Serum Leptin Levels are Associated With an Increased Risk of Sentinel Lymph Node Metastasis in Cutaneous Melanoma. Medicine (Baltimore). 2016 Mar;95(11):e3073.
Oba, Junna, et al. “Elevated Serum Leptin Levels are Associated With an Increased Risk of Sentinel Lymph Node Metastasis in Cutaneous Melanoma.Medicine (Baltimore), vol. 95, no. 11, Mar. 2016, p. e3073. Pubmed, doi:10.1097/MD.0000000000003073.
Oba J, Wei W, Gershenwald JE, Johnson MM, Wyatt CM, Ellerhorst JA, Grimm EA. Elevated Serum Leptin Levels are Associated With an Increased Risk of Sentinel Lymph Node Metastasis in Cutaneous Melanoma. Medicine (Baltimore). 2016 Mar;95(11):e3073.

Published In

Medicine (Baltimore)

DOI

EISSN

1536-5964

Publication Date

March 2016

Volume

95

Issue

11

Start / End Page

e3073

Location

United States

Related Subject Headings

  • Texas
  • Skin Neoplasms
  • Sentinel Lymph Node Biopsy
  • Prospective Studies
  • Middle Aged
  • Melanoma
  • Male
  • Lymphatic Metastasis
  • Leptin
  • Humans