Proton pump inhibitors and chronic kidney disease: is it time to sound the alarm?

Journal Article (Editorial)

Proton pump inhibitors are widely used worldwide for the management of gastroesophageal reflux, but have been associated with the development of interstitial nephritis and acute kidney injury. A large observational study using data from the Atherosclerosis Risk in Communities cohort and the Geisinger Health System demonstrates an association between the use of proton pump inhibitors and chronic kidney disease. Although the study does not prove causality, the robustness of the findings in two cohorts suggests a need for further study and reevaluation of the safety of these agents for widespread, non-prescription use.

Full Text

Duke Authors

Cited Authors

  • Wyatt, CM

Published Date

  • April 2016

Published In

Volume / Issue

  • 89 / 4

Start / End Page

  • 732 - 733

PubMed ID

  • 26994567

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1016/j.kint.2016.02.007

Language

  • eng

Conference Location

  • United States