Fibroblast growth factor receptor 4: the missing link between chronic kidney disease and FGF23-induced left ventricular hypertrophy?

Journal Article

Serum phosphorus and the regulatory hormone fibroblast growth factor 23 have been strongly linked to cardiovascular morbidity and mortality in patients with chronic kidney disease. A recent study identified fibroblast growth factor receptor 4 as the primary receptor mediating the effect of fibroblast growth factor 23 on left ventricular hypertrophy, providing new mechanistic insights and a potential therapeutic target to reduce cardiovascular morbidity in chronic kidney disease.

Full Text

Duke Authors

Cited Authors

  • Wyatt, CM; Drüeke, TB

Published Date

  • January 2016

Published In

Volume / Issue

  • 89 / 1

Start / End Page

  • 7 - 9

PubMed ID

  • 26759036

Pubmed Central ID

  • 26759036

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1016/j.kint.2015.11.012


  • eng

Conference Location

  • United States