Antiretroviral therapy and the kidney.


Journal Article (Review)

Acute kidney injury (AKI) and chronic kidney disease (CKD) are more common in the HIV-infected population than in the general population. AKI is associated with an increased risk of heart failure, cardiovascular disease, end-stage renal disease (ESRD), and mortality. Tenofovir is associated with severe AKI in a small percentage of patients and with subclinical abnormalities in many more. HIV-associated nephropathy is now a relatively rare form of CKD, because of the widespread use of potent antiretroviral therapy. The CKD spectrum in HIV-infected patients has become more frequently characterized by comorbid CKD, with an increased frequency of CKD related to diabetes or hypertension being observed. Kidney transplantation is a therapeutic option for HIV-infected patients with ESRD if their HIV infection is controlled, although rates of acute graft rejection and drug-drug interactions are high. This article summarizes a presentation by Christina M. Wyatt, MD, at the IAS-USA continuing education program held in Washington, DC, in June 2013.

Full Text

Duke Authors

Cited Authors

  • Wyatt, CM

Published Date

  • June 2014

Published In

Volume / Issue

  • 22 / 3

Start / End Page

  • 655 - 658

PubMed ID

  • 25101531

Pubmed Central ID

  • 25101531

Electronic International Standard Serial Number (EISSN)

  • 2161-5853


  • eng

Conference Location

  • United States