Skip to main content

Fanconi syndrome accompanied by renal function decline with tenofovir disoproxil fumarate: a prospective, case-control study of predictors and resolution in HIV-infected patients.

Publication ,  Journal Article
Gupta, SK; Anderson, AM; Ebrahimi, R; Fralich, T; Graham, H; Scharen-Guivel, V; Flaherty, JF; Fortin, C; Kalayjian, RC; Rachlis, A; Wyatt, CM
Published in: PLoS One
2014

OBJECTIVE: The predictors of Fanconi syndrome (FS) accompanied by renal function decline with use of the antiretroviral tenofovir disoproxil fumarate (TDF) have not been assessed. In addition, the natural history of renal recovery from FS after TDF discontinuation is not well-described. DESIGN: We prospectively enrolled HIV-infected patients receiving TDF with newly identified FS (defined as at least two markers of proximal tubulopathy and either a >25% decline in creatinine clearance (CrCl) from pre-TDF values or a CrCl <60 mL/min in those without a known pre-TDF CrCl) in a multicenter observational study. These case participants were matched 1:2 to controls; characteristics between the two groups were compared. Case participants with known pre-TDF CrCl values were then followed over 48 weeks to assess renal recovery. RESULTS: Nineteen cases and 37 controls were enrolled. In multivariable analysis, previous or concurrent use of lopinavir/ritonavir [OR 16.37, 95% CI (2.28, 117.68); P = 0.006] and reduced creatinine clearance prior to initiation of TDF [OR 1.44 for every 5 mL/min reduction, 95% CI (1.09, 1.92); P = 0.012; OR 19.77 for pre-TDF CrCl lower than 83 mL/min, 95% CI (2.24, 174.67); P = 0.007] were significantly associated with FS. Of the 14 cases followed for resolution, 7 (50%) achieved at least partial resolution (defined as recovering CrCl >70% of pre-TDF values) although most participants had full normalization of proximal tubulopathy markers within two months of TDF discontinuation. CONCLUSIONS: FS, defined by specific CrCl decreases and markers of tubulopathy, is more likely in those who have received or are currently receiving concomitant lopinavir/ritonavir or who had lower CrCl prior to TDF initiation. Half of those with protocol-defined FS had CrCl recover to near pre-TDF values during the first year after TDF discontinuation.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2014

Volume

9

Issue

3

Start / End Page

e92717

Location

United States

Related Subject Headings

  • Tenofovir
  • Risk Factors
  • Prospective Studies
  • Prognosis
  • Organophosphonates
  • Middle Aged
  • Male
  • Kidney Function Tests
  • Kidney Diseases
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gupta, S. K., Anderson, A. M., Ebrahimi, R., Fralich, T., Graham, H., Scharen-Guivel, V., … Wyatt, C. M. (2014). Fanconi syndrome accompanied by renal function decline with tenofovir disoproxil fumarate: a prospective, case-control study of predictors and resolution in HIV-infected patients. PLoS One, 9(3), e92717. https://doi.org/10.1371/journal.pone.0092717
Gupta, Samir K., Albert M. Anderson, Ramin Ebrahimi, Todd Fralich, Hiba Graham, Valeska Scharen-Guivel, John F. Flaherty, et al. “Fanconi syndrome accompanied by renal function decline with tenofovir disoproxil fumarate: a prospective, case-control study of predictors and resolution in HIV-infected patients.PLoS One 9, no. 3 (2014): e92717. https://doi.org/10.1371/journal.pone.0092717.
Gupta SK, Anderson AM, Ebrahimi R, Fralich T, Graham H, Scharen-Guivel V, Flaherty JF, Fortin C, Kalayjian RC, Rachlis A, Wyatt CM. Fanconi syndrome accompanied by renal function decline with tenofovir disoproxil fumarate: a prospective, case-control study of predictors and resolution in HIV-infected patients. PLoS One. 2014;9(3):e92717.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2014

Volume

9

Issue

3

Start / End Page

e92717

Location

United States

Related Subject Headings

  • Tenofovir
  • Risk Factors
  • Prospective Studies
  • Prognosis
  • Organophosphonates
  • Middle Aged
  • Male
  • Kidney Function Tests
  • Kidney Diseases
  • Humans