APOL1 variants in HIV-associated nephropathy: just one piece of the puzzle.

Journal Article (Journal Article)

Considerable attention has been focused on how the APOL1/MYH9 locus determines susceptibility to focal segmental glomerulosclerosis, including HIV-associated nephropathy (HIVAN). Atta and colleagues found that homozygosity for APOL1 risk alleles was associated with many, but not all, HIVAN cases, and that APOL1 variation failed to predict characteristics of disease. Their work gives important impetus to identify other genetic and environmental factors that may provide a 'second hit' linking HIV infection to HIVAN.

Full Text

Duke Authors

Cited Authors

  • Hays, T; Wyatt, CM

Published Date

  • August 2012

Published In

Volume / Issue

  • 82 / 3

Start / End Page

  • 259 - 260

PubMed ID

  • 22791322

Electronic International Standard Serial Number (EISSN)

  • 1523-1755

Digital Object Identifier (DOI)

  • 10.1038/ki.2012.129

Language

  • eng

Conference Location

  • United States