The New Epidemiology of HIV-Related Kidney Disease.

Journal Article (Journal Article)

HIV-related kidney disease has been associated with significant morbidity and mortality in the HIV population. It is clear that the epidemiology of HIV-related kidney disease has changed dramatically since the first case reports in 1984. During these early years, the predominant etiology of kidney disease in HIV was recognized as HIV-associated nephropathy (HIVAN), an aggressive form of kidney disease with a high rate of progression to end-stage renal disease (ESRD). Subsequently, with the widespread use of combination antiretroviral therapy (cART), there was a dramatic decrease in the incidence of ESRD attributed to HIV/AIDS. Although the incidence of HIV-related ESRD has plateaued in the last 15 years, the prevalence has continued to increase because of improved survival. Available prevalence estimates do not include HIV-infected individuals with comorbid ESRD, although there is growing evidence that the epidemiology of kidney disease in the HIV-infected population has changed. This article reviews the impact of risk factors such as race, diabetes mellitus, hypertension, hepatitis C virus coinfection, and the chronic use of cART on the changing epidemiology of HIV-related kidney disease. Additionally in this review, we propose potential areas of translational research that will help to further characterize HIV-related kidney disease in the 21st century.

Full Text

Duke Authors

Cited Authors

  • Mallipattu, SK; Wyatt, CM; He, JC

Published Date

  • 2012

Published In

Volume / Issue

  • Suppl 4 /

Start / End Page

  • 001 -

PubMed ID

  • 25309811

Pubmed Central ID

  • PMC4190040

International Standard Serial Number (ISSN)

  • 2155-6113

Digital Object Identifier (DOI)

  • 10.4172/2155-6113.S4-001

Language

  • eng

Conference Location

  • United States