Microalbuminuria is associated with all-cause and AIDS mortality in women with HIV infection.

Journal Article (Journal Article)

Objectives

Prevalence of microalbuminuria is increased in patients with HIV. Microalbuminuria is associated with increased mortality in other populations, including diabetics, for whom microalbuminuria testing is standard of care. We investigated whether microalbuminuria is associated with mortality in HIV-infected women not receiving antiretroviral therapy.

Methods

Urinalysis for proteinuria and semiquantitative testing for microalbuminuria were performed in specimens from 2 consecutive visits in 1547 HIV-infected women enrolled in the Women's Interagency HIV Study in 1994-1995. Time to death was modeled using proportional hazards analysis.

Results

Compared with women without albuminuria, the hazard ratio (HR) for all-cause mortality was increased in women with 1 (HR: 3.4; 95% CI: 2.2 to 5.2) or 2 specimens positive for either proteinuria or microalbuminuria (HR: 3.9; 95% CI: 2.1 to 7.0). The highest risk was observed in women with both specimens positive for proteinuria (HR: 5.8; 95% CI: 3.4 to 9.8). The association between albuminuria and all-cause mortality risk remained significant after adjustment for demographics, HIV disease severity, and related comorbidities. Similar results were obtained for AIDS death.

Conclusions

We identified a graded relationship between albuminuria and the risk of all-cause and AIDS mortality.

Full Text

Duke Authors

Cited Authors

  • Wyatt, CM; Hoover, DR; Shi, Q; Seaberg, E; Wei, C; Tien, PC; Karim, R; Lazar, J; Young, MA; Cohen, MH; Klotman, PE; Anastos, K

Published Date

  • September 2010

Published In

Volume / Issue

  • 55 / 1

Start / End Page

  • 73 - 77

PubMed ID

  • 20098331

Pubmed Central ID

  • PMC2888617

Electronic International Standard Serial Number (EISSN)

  • 1944-7884

International Standard Serial Number (ISSN)

  • 1525-4135

Digital Object Identifier (DOI)

  • 10.1097/qai.0b013e3181cc1070

Language

  • eng