Urinary NGAL marks cystic disease in HIV-associated nephropathy.

Published

Journal Article

Nephrosis and a rapid decline in kidney function characterize HIV-associated nephropathy (HIVAN). Histologically, HIVAN is a collapsing focal segmental glomerulosclerosis with prominent tubular damage. We explored the expression of neutrophil gelatinase-associated lipocalin (NGAL), a marker of tubular injury, to determine whether this protein has the potential to aid in the noninvasive diagnosis of HIVAN. We found that expression of urinary NGAL was much higher in patients with biopsy-proven HIVAN than in HIV-positive and HIV-negative patients with other forms of chronic kidney disease. In the HIV-transgenic mouse model of HIVAN, NGAL mRNA was abundant in dilated, microcystic segments of the nephron. In contrast, urinary NGAL did not correlate with proteinuria in human or in mouse models. These data show that marked upregulation of NGAL accompanies HIVAN and support further study of uNGAL levels in large cohorts to aid in the noninvasive diagnosis of HIVAN and screen for HIVAN-related tubular damage.

Full Text

Duke Authors

Cited Authors

  • Paragas, N; Nickolas, TL; Wyatt, C; Forster, CS; Sise, M; Morgello, S; Jagla, B; Buchen, C; Stella, P; Sanna-Cherchi, S; Carnevali, ML; Mattei, S; Bovino, A; Argentiero, L; Magnano, A; Devarajan, P; Schmidt-Ott, KM; Allegri, L; Klotman, P; D'Agati, V; Gharavi, AG; Barasch, J

Published Date

  • August 2009

Published In

Volume / Issue

  • 20 / 8

Start / End Page

  • 1687 - 1692

PubMed ID

  • 19628667

Pubmed Central ID

  • 19628667

Electronic International Standard Serial Number (EISSN)

  • 1533-3450

Digital Object Identifier (DOI)

  • 10.1681/ASN.2009010065

Language

  • eng

Conference Location

  • United States