Data and scripts from: Obtaining soft matter models of proteins and their phase behavior


Globular proteins are roughly spherical biomolecules with attractive, and highly directional interactions. This microscopic observation motivates describing these proteins as patchy particles: hard spheres with attractive surface patches. Mapping a biomolecule to a patchy model requires simplifying effective protein-protein interactions, which in turn provides a microscopic understanding of the protein solution behavior. The patchy model can indeed be fully analyzed, including its phase diagram. In this chapter, we detail the methodology of mapping a given protein to a patchy model and of determining the phase diagram of the latter. We also briefly describe the theory upon which the methodology is based, provide practical information, and discuss potential pitfalls.

Data Access

Duke Authors

Cited Authors

  • Altan, I; Charbonneau, P

Published Date

  • February 4, 2019

Digital Object Identifier (DOI)

  • 10.7924/r4ww7bs1p