Correlation Between 3D ARFI and Quantitative Imaging Metrics from SWEI and Multi-Parametric MRI in Vivo in Normal and Cancerous Prostate Tissue


Conference Paper

© 2018 IEEE. Prostate lesions and healthy regions from 12 radical prostatectomy patients were identified in acoustic radiation force impulse (ARFI) imaging, shear wave elasticity imaging (SWEI), and multi-parametric magnetic resonance imaging (mpMRI) apparent diffusion coefficient (ADC) data and confirmed by histopathology. Custom sequencing and processing techniques led to ARFI and SWEI images which demonstrate strong structural concordance. The combination of quantitative metrics from multiple imaging modalities using a principal component binary discriminator improved the diagnostic capability over individual modalities with areas under the receiver operating characteristic curve reaching 0.94. The correlations among the separate modality parameters were moderate with R-squared values between 0.47 (ADC and ARFI) and 0.71 (ARFI and SWEI).

Full Text

Duke Authors

Cited Authors

  • Cody Morris, D; Chan, DY; Palmeri, ML; Glass, TJ; McCormick, MM; Jack Tay, K; Polascik, TJ; Gupta, RT; Nightingale, KR

Published Date

  • January 1, 2018

Published In

Volume / Issue

  • 2018-January /

Electronic International Standard Serial Number (EISSN)

  • 1948-5727

International Standard Serial Number (ISSN)

  • 1948-5719

Digital Object Identifier (DOI)

  • 10.1109/ULTSYM.2018.8579729

Citation Source

  • Scopus