© 2018 IEEE. Prostate lesions and healthy regions from 12 radical prostatectomy patients were identified in acoustic radiation force impulse (ARFI) imaging, shear wave elasticity imaging (SWEI), and multi-parametric magnetic resonance imaging (mpMRI) apparent diffusion coefficient (ADC) data and confirmed by histopathology. Custom sequencing and processing techniques led to ARFI and SWEI images which demonstrate strong structural concordance. The combination of quantitative metrics from multiple imaging modalities using a principal component binary discriminator improved the diagnostic capability over individual modalities with areas under the receiver operating characteristic curve reaching 0.94. The correlations among the separate modality parameters were moderate with R-squared values between 0.47 (ADC and ARFI) and 0.71 (ARFI and SWEI).