Skip to main content
Journal cover image

Physiological state gates acquisition and expression of mesolimbic reward prediction signals.

Publication ,  Journal Article
Cone, JJ; Fortin, SM; McHenry, JA; Stuber, GD; McCutcheon, JE; Roitman, MF
Published in: Proceedings of the National Academy of Sciences of the United States of America
February 2016

Phasic dopamine signaling participates in associative learning by reinforcing associations between outcomes (unconditioned stimulus; US) and their predictors (conditioned stimulus; CS). However, prior work has always engendered these associations with innately rewarding stimuli. Thus, whether dopamine neurons can acquire prediction signals in the absence of appetitive experience and update them when the value of the outcome changes remains unknown. Here, we used sodium depletion to reversibly manipulate the appetitive value of a hypertonic sodium solution while measuring phasic dopamine signaling in rat nucleus accumbens. Dopamine responses to the NaCl US following sodium depletion updated independent of prior experience. In contrast, prediction signals were only acquired through extensive experience with a US that had positive affective value. Once learned, dopamine prediction signals were flexibly expressed in a state-dependent manner. Our results reveal striking differences with respect to how physiological state shapes dopamine signals evoked by outcomes and their predictors.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

February 2016

Volume

113

Issue

7

Start / End Page

1943 / 1948

Related Subject Headings

  • Sodium Chloride, Dietary
  • Reward
  • Rats, Sprague-Dawley
  • Rats
  • Male
  • Limbic System
  • Appetite
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cone, J. J., Fortin, S. M., McHenry, J. A., Stuber, G. D., McCutcheon, J. E., & Roitman, M. F. (2016). Physiological state gates acquisition and expression of mesolimbic reward prediction signals. Proceedings of the National Academy of Sciences of the United States of America, 113(7), 1943–1948. https://doi.org/10.1073/pnas.1519643113
Cone, Jackson J., Samantha M. Fortin, Jenna A. McHenry, Garret D. Stuber, James E. McCutcheon, and Mitchell F. Roitman. “Physiological state gates acquisition and expression of mesolimbic reward prediction signals.Proceedings of the National Academy of Sciences of the United States of America 113, no. 7 (February 2016): 1943–48. https://doi.org/10.1073/pnas.1519643113.
Cone JJ, Fortin SM, McHenry JA, Stuber GD, McCutcheon JE, Roitman MF. Physiological state gates acquisition and expression of mesolimbic reward prediction signals. Proceedings of the National Academy of Sciences of the United States of America. 2016 Feb;113(7):1943–8.
Cone, Jackson J., et al. “Physiological state gates acquisition and expression of mesolimbic reward prediction signals.Proceedings of the National Academy of Sciences of the United States of America, vol. 113, no. 7, Feb. 2016, pp. 1943–48. Epmc, doi:10.1073/pnas.1519643113.
Cone JJ, Fortin SM, McHenry JA, Stuber GD, McCutcheon JE, Roitman MF. Physiological state gates acquisition and expression of mesolimbic reward prediction signals. Proceedings of the National Academy of Sciences of the United States of America. 2016 Feb;113(7):1943–1948.
Journal cover image

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

February 2016

Volume

113

Issue

7

Start / End Page

1943 / 1948

Related Subject Headings

  • Sodium Chloride, Dietary
  • Reward
  • Rats, Sprague-Dawley
  • Rats
  • Male
  • Limbic System
  • Appetite
  • Animals