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Coordination of Brain-Wide Activity Dynamics by Dopaminergic Neurons.

Publication ,  Journal Article
Decot, HK; Namboodiri, VMK; Gao, W; McHenry, JA; Jennings, JH; Lee, S-H; Kantak, PA; Jill Kao, Y-C; Das, M; Witten, IB; Deisseroth, K ...
Published in: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
February 2017

Several neuropsychiatric conditions, such as addiction and schizophrenia, may arise in part from dysregulated activity of ventral tegmental area dopaminergic (THVTA) neurons, as well as from more global maladaptation in neurocircuit function. However, whether THVTA activity affects large-scale brain-wide function remains unknown. Here we selectively activated THVTA neurons in transgenic rats and measured resulting changes in whole-brain activity using stimulus-evoked functional magnetic resonance imaging. Applying a standard generalized linear model analysis approach, our results indicate that selective optogenetic stimulation of THVTA neurons enhanced cerebral blood volume signals in striatal target regions in a dopamine receptor-dependent manner. However, brain-wide voxel-based principal component analysis of the same data set revealed that dopaminergic modulation activates several additional anatomically distinct regions throughout the brain, not typically associated with dopamine release events. Furthermore, explicit pairing of THVTA neuronal activation with a forepaw stimulus of a particular frequency expanded the sensory representation of that stimulus, not exclusively within the somatosensory cortices, but brain-wide. These data suggest that modulation of THVTA neurons can impact brain dynamics across many distributed anatomically distinct regions, even those that receive little to no direct THVTA input.

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Published In

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

DOI

EISSN

1740-634X

ISSN

0893-133X

Publication Date

February 2017

Volume

42

Issue

3

Start / End Page

615 / 627

Related Subject Headings

  • Ventral Tegmental Area
  • Receptors, Dopamine D1
  • Rats, Long-Evans
  • Rats
  • Psychiatry
  • Male
  • Magnetic Resonance Imaging
  • Functional Neuroimaging
  • Dopaminergic Neurons
  • Dopamine
 

Citation

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Decot, H. K., Namboodiri, V. M. K., Gao, W., McHenry, J. A., Jennings, J. H., Lee, S.-H., … Stuber, G. D. (2017). Coordination of Brain-Wide Activity Dynamics by Dopaminergic Neurons. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 42(3), 615–627. https://doi.org/10.1038/npp.2016.151
Decot, Heather K., Vijay M. K. Namboodiri, Wei Gao, Jenna A. McHenry, Joshua H. Jennings, Sung-Ho Lee, Pranish A. Kantak, et al. “Coordination of Brain-Wide Activity Dynamics by Dopaminergic Neurons.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 42, no. 3 (February 2017): 615–27. https://doi.org/10.1038/npp.2016.151.
Decot HK, Namboodiri VMK, Gao W, McHenry JA, Jennings JH, Lee S-H, et al. Coordination of Brain-Wide Activity Dynamics by Dopaminergic Neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2017 Feb;42(3):615–27.
Decot, Heather K., et al. “Coordination of Brain-Wide Activity Dynamics by Dopaminergic Neurons.Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 42, no. 3, Feb. 2017, pp. 615–27. Epmc, doi:10.1038/npp.2016.151.
Decot HK, Namboodiri VMK, Gao W, McHenry JA, Jennings JH, Lee S-H, Kantak PA, Jill Kao Y-C, Das M, Witten IB, Deisseroth K, Shih Y-YI, Stuber GD. Coordination of Brain-Wide Activity Dynamics by Dopaminergic Neurons. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2017 Feb;42(3):615–627.

Published In

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

DOI

EISSN

1740-634X

ISSN

0893-133X

Publication Date

February 2017

Volume

42

Issue

3

Start / End Page

615 / 627

Related Subject Headings

  • Ventral Tegmental Area
  • Receptors, Dopamine D1
  • Rats, Long-Evans
  • Rats
  • Psychiatry
  • Male
  • Magnetic Resonance Imaging
  • Functional Neuroimaging
  • Dopaminergic Neurons
  • Dopamine