Neuro-Immune Mechanisms Regulating Social Behavior: Dopamine as Mediator?

Journal Article (Review;Journal Article)

Social interactions are fundamental to survival and overall health. The mechanisms underlying social behavior are complex, but we now know that immune signaling plays a fundamental role in the regulation of social interactions. Prolonged or exaggerated alterations in social behavior often accompany altered immune signaling and function in pathological states. Thus, unraveling the link between social behavior and immune signaling is a fundamental challenge, not only to advance our understanding of human health and development, but for the design of comprehensive therapeutic approaches for neural disorders. In this review, we synthesize literature demonstrating the bidirectional relationship between social behavior and immune signaling and highlight recent work linking social behavior, immune function, and dopaminergic signaling in adolescent neural and behavioral development.

Full Text

Duke Authors

Cited Authors

  • Kopec, AM; Smith, CJ; Bilbo, SD

Published Date

  • May 2019

Published In

Volume / Issue

  • 42 / 5

Start / End Page

  • 337 - 348

PubMed ID

  • 30890276

Pubmed Central ID

  • PMC6486862

Electronic International Standard Serial Number (EISSN)

  • 1878-108X

International Standard Serial Number (ISSN)

  • 0166-2236

Digital Object Identifier (DOI)

  • 10.1016/j.tins.2019.02.005


  • eng