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Neuro-Immune Mechanisms Regulating Social Behavior: Dopamine as Mediator?

Publication ,  Journal Article
Kopec, AM; Smith, CJ; Bilbo, SD
Published in: Trends in neurosciences
May 2019

Social interactions are fundamental to survival and overall health. The mechanisms underlying social behavior are complex, but we now know that immune signaling plays a fundamental role in the regulation of social interactions. Prolonged or exaggerated alterations in social behavior often accompany altered immune signaling and function in pathological states. Thus, unraveling the link between social behavior and immune signaling is a fundamental challenge, not only to advance our understanding of human health and development, but for the design of comprehensive therapeutic approaches for neural disorders. In this review, we synthesize literature demonstrating the bidirectional relationship between social behavior and immune signaling and highlight recent work linking social behavior, immune function, and dopaminergic signaling in adolescent neural and behavioral development.

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Published In

Trends in neurosciences

DOI

EISSN

1878-108X

ISSN

0166-2236

Publication Date

May 2019

Volume

42

Issue

5

Start / End Page

337 / 348

Related Subject Headings

  • Social Behavior
  • Reward
  • Neurology & Neurosurgery
  • Neuroimmunomodulation
  • Immunity, Cellular
  • Humans
  • Dopamine
  • Brain
  • Animals
  • 5203 Clinical and health psychology
 

Citation

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Kopec, A. M., Smith, C. J., & Bilbo, S. D. (2019). Neuro-Immune Mechanisms Regulating Social Behavior: Dopamine as Mediator? Trends in Neurosciences, 42(5), 337–348. https://doi.org/10.1016/j.tins.2019.02.005
Kopec, Ashley M., Caroline J. Smith, and Staci D. Bilbo. “Neuro-Immune Mechanisms Regulating Social Behavior: Dopamine as Mediator?Trends in Neurosciences 42, no. 5 (May 2019): 337–48. https://doi.org/10.1016/j.tins.2019.02.005.
Kopec AM, Smith CJ, Bilbo SD. Neuro-Immune Mechanisms Regulating Social Behavior: Dopamine as Mediator? Trends in neurosciences. 2019 May;42(5):337–48.
Kopec, Ashley M., et al. “Neuro-Immune Mechanisms Regulating Social Behavior: Dopamine as Mediator?Trends in Neurosciences, vol. 42, no. 5, May 2019, pp. 337–48. Epmc, doi:10.1016/j.tins.2019.02.005.
Kopec AM, Smith CJ, Bilbo SD. Neuro-Immune Mechanisms Regulating Social Behavior: Dopamine as Mediator? Trends in neurosciences. 2019 May;42(5):337–348.
Journal cover image

Published In

Trends in neurosciences

DOI

EISSN

1878-108X

ISSN

0166-2236

Publication Date

May 2019

Volume

42

Issue

5

Start / End Page

337 / 348

Related Subject Headings

  • Social Behavior
  • Reward
  • Neurology & Neurosurgery
  • Neuroimmunomodulation
  • Immunity, Cellular
  • Humans
  • Dopamine
  • Brain
  • Animals
  • 5203 Clinical and health psychology