Role of T-cell activation in salt-sensitive hypertension.

Journal Article (Journal Article;Review)

The contributions of T lymphocytes to the pathogenesis of salt-sensitive hypertension has been well established. Under hypertensive stimuli, naive T cells develop into different subsets, including Th1, Th2, Th17, Treg, and cytotoxic CD8+ T cells, depending on the surrounding microenviroment in organs. Distinct subsets of T cells may play totally different roles in tissue damage and hypertension. The underlying mechanisms by which hypertensive stimuli activate naive T cells involve many events and different organs, such as neoantigen presentation by dendritic cells, high salt concentration, and the milieu of oxidative stress in the kidney and vasculature. Infiltrating and activated T subsets in injured organs, in turn, exert considerable impacts on tissue dysfunction, including sodium retention in the kidney, vascular stiffness, and remodeling in the vasculature. Therefore, a thorough knowledge of T-cell actions in hypertension may provide novel insights into the development of new therapeutic strategies for patients with hypertension.

Full Text

Duke Authors

Cited Authors

  • Ren, J; Crowley, SD

Published Date

  • June 1, 2019

Published In

Volume / Issue

  • 316 / 6

Start / End Page

  • H1345 - H1353

PubMed ID

  • 30901277

Pubmed Central ID

  • PMC6620682

Electronic International Standard Serial Number (EISSN)

  • 1522-1539

Digital Object Identifier (DOI)

  • 10.1152/ajpheart.00096.2019


  • eng

Conference Location

  • United States