Efficient synthesis of unsymmetrical sulfamides from sulfamic acid salts by activation with triphenylphosphine ditriflate


Journal Article

© 2019 Elsevier Ltd A general approach to prepare unsymmetrical sulfamides is described. This method relies on the activation of sulfamic acid salts with triphenylphosphine ditriflate, and subsequent trapping by a nucleophilic amine. This strategy improves access to N-octadecyl-N′-propylsulfamide, a feeding suppressant.

Full Text

Duke Authors

Cited Authors

  • Shehata, MF; Short, MA; Sanders, MA; Roizen, JL

Published Date

  • June 14, 2019

Published In

Volume / Issue

  • 75 / 24

Start / End Page

  • 3186 - 3194

Electronic International Standard Serial Number (EISSN)

  • 1464-5416

International Standard Serial Number (ISSN)

  • 0040-4020

Digital Object Identifier (DOI)

  • 10.1016/j.tet.2019.02.063

Citation Source

  • Scopus