High-fructose corn syrup enhances intestinal tumor growth in mice.


Journal Article

Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and metabolic syndrome. HFCS increased the concentrations of fructose and glucose in the intestinal lumen and serum, respectively, and the tumors transported both sugars. Within the tumors, fructose was converted to fructose-1-phosphate, leading to activation of glycolysis and increased synthesis of fatty acids that support tumor growth. These mouse studies support the hypothesis that the combination of dietary glucose and fructose, even at a moderate dose, can enhance tumorigenesis.

Full Text

Duke Authors

Cited Authors

  • Goncalves, MD; Lu, C; Tutnauer, J; Hartman, TE; Hwang, S-K; Murphy, CJ; Pauli, C; Morris, R; Taylor, S; Bosch, K; Yang, S; Wang, Y; Van Riper, J; Lekaye, HC; Roper, J; Kim, Y; Chen, Q; Gross, SS; Rhee, KY; Cantley, LC; Yun, J

Published Date

  • March 22, 2019

Published In

Volume / Issue

  • 363 / 6433

Start / End Page

  • 1345 - 1349

PubMed ID

  • 30898933

Pubmed Central ID

  • 30898933

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.aat8515


  • eng

Conference Location

  • United States