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High-fructose corn syrup enhances intestinal tumor growth in mice.

Publication ,  Journal Article
Goncalves, MD; Lu, C; Tutnauer, J; Hartman, TE; Hwang, S-K; Murphy, CJ; Pauli, C; Morris, R; Taylor, S; Bosch, K; Yang, S; Wang, Y; Roper, J ...
Published in: Science
March 22, 2019

Excessive consumption of beverages sweetened with high-fructose corn syrup (HFCS) is associated with obesity and with an increased risk of colorectal cancer. Whether HFCS contributes directly to tumorigenesis is unclear. We investigated the effects of daily oral administration of HFCS in adenomatous polyposis coli (APC) mutant mice, which are predisposed to develop intestinal tumors. The HFCS-treated mice showed a substantial increase in tumor size and tumor grade in the absence of obesity and metabolic syndrome. HFCS increased the concentrations of fructose and glucose in the intestinal lumen and serum, respectively, and the tumors transported both sugars. Within the tumors, fructose was converted to fructose-1-phosphate, leading to activation of glycolysis and increased synthesis of fatty acids that support tumor growth. These mouse studies support the hypothesis that the combination of dietary glucose and fructose, even at a moderate dose, can enhance tumorigenesis.

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Published In

Science

DOI

EISSN

1095-9203

Publication Date

March 22, 2019

Volume

363

Issue

6433

Start / End Page

1345 / 1349

Location

United States

Related Subject Headings

  • Tumor Burden
  • Neoplasm Grading
  • Mice, Mutant Strains
  • Mice
  • Intestinal Neoplasms
  • High Fructose Corn Syrup
  • General Science & Technology
  • Diet
  • Carcinogenesis
  • Animals
 

Citation

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Goncalves, M. D., Lu, C., Tutnauer, J., Hartman, T. E., Hwang, S.-K., Murphy, C. J., … Yun, J. (2019). High-fructose corn syrup enhances intestinal tumor growth in mice. Science, 363(6433), 1345–1349. https://doi.org/10.1126/science.aat8515
Goncalves, Marcus D., Changyuan Lu, Jordan Tutnauer, Travis E. Hartman, Seo-Kyoung Hwang, Charles J. Murphy, Chantal Pauli, et al. “High-fructose corn syrup enhances intestinal tumor growth in mice.Science 363, no. 6433 (March 22, 2019): 1345–49. https://doi.org/10.1126/science.aat8515.
Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang S-K, Murphy CJ, et al. High-fructose corn syrup enhances intestinal tumor growth in mice. Science. 2019 Mar 22;363(6433):1345–9.
Goncalves, Marcus D., et al. “High-fructose corn syrup enhances intestinal tumor growth in mice.Science, vol. 363, no. 6433, Mar. 2019, pp. 1345–49. Pubmed, doi:10.1126/science.aat8515.
Goncalves MD, Lu C, Tutnauer J, Hartman TE, Hwang S-K, Murphy CJ, Pauli C, Morris R, Taylor S, Bosch K, Yang S, Wang Y, Van Riper J, Lekaye HC, Roper J, Kim Y, Chen Q, Gross SS, Rhee KY, Cantley LC, Yun J. High-fructose corn syrup enhances intestinal tumor growth in mice. Science. 2019 Mar 22;363(6433):1345–1349.
Journal cover image

Published In

Science

DOI

EISSN

1095-9203

Publication Date

March 22, 2019

Volume

363

Issue

6433

Start / End Page

1345 / 1349

Location

United States

Related Subject Headings

  • Tumor Burden
  • Neoplasm Grading
  • Mice, Mutant Strains
  • Mice
  • Intestinal Neoplasms
  • High Fructose Corn Syrup
  • General Science & Technology
  • Diet
  • Carcinogenesis
  • Animals