Overview of genetically engineered mouse models of colorectal carcinoma to enable translational biology and drug development.

Published online

Journal Article

Preclinical models for colorectal cancer (CRC) are critical for translational biology and drug development studies to characterize and treat this condition. Mouse models of human cancer are particularly popular because of their relatively low cost, short life span, and ease of use. Genetically engineered mouse models (GEMMs) of CRC are engineered from germline or somatic modification of critical tumor suppressor genes and/or oncogenes that drive mutations in human disease. Detailed in this overview are the salient features of several useful colorectal cancer GEMMs and their value as tools for translational biology and preclinical drug development.

Full Text

Duke Authors

Cited Authors

  • Roper, J; Martin, ES; Hung, KE

Published Date

  • June 16, 2014

Published In

Volume / Issue

  • 65 /

Start / End Page

  • 14.29.1 - 14.2910

PubMed ID

  • 24934606

Pubmed Central ID

  • 24934606

Electronic International Standard Serial Number (EISSN)

  • 1934-8290

Digital Object Identifier (DOI)

  • 10.1002/0471141755.ph1429s65

Language

  • eng

Conference Location

  • United States