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Chronological development of elevated aminotransferases in a nonalcoholic population.

Publication ,  Journal Article
Suzuki, A; Angulo, P; Lymp, J; St Sauver, J; Muto, A; Okada, T; Lindor, K
Published in: Hepatology
January 2005

The incidence and risk factors of nonalcoholic fatty liver disease (NAFLD) have never been prospectively determined. To determine the frequency and risk factors of NAFLD and chronological ordering between NAFLD, weight gain, and features of insulin resistance, a historical cohort study was conducted in a Japanese workplace. A cohort free of previous liver injury, alcohol consumption of more than 140 g/wk, and hepatitis B or C infection (529 of 1537 subjects), and a subcohort of 287 subjects free of insulin resistance-related features were identified. Elevated aminotransferases in nonalcoholics were used as a surrogate for NAFLD. High aminotransferases together with weight gain of more than 2 kg and insulin resistance-related features in the subcohort were sought for up to 5 years. The incidence of high aminotransferases was 31 per 1000 person-years (71 events). A significant interaction occurred between age and sex in the development of high aminotransferases. In subjects younger than age 40 years, male sex (hazard ratio [HR]: 4.6), elevated body mass index (HR: 2.1), hypertension (HR: 2.6), and low high-density lipoprotein cholesterol (HR: 2.8) increased the risk of high aminotransferases, whereas age (HR: 0.6 for each 5 years) decreased the risk. In subjects older than age 40 years, glucose intolerance (HR: 5.3) was the only significant risk factor. In the subcohort, weight gain preceded high aminotransferases and other insulin resistance-related features, which appeared sequentially in order of low high-density lipoprotein cholesterol, hypertriglyceridemia/hypertransaminasemia/hypertension, and glucose intolerance. In conclusion, this cohort study clearly showed chronological ordering and an association between development of elevated aminotransferases and risk factors of NAFLD.

Duke Scholars

Published In

Hepatology

DOI

ISSN

0270-9139

Publication Date

January 2005

Volume

41

Issue

1

Start / End Page

64 / 71

Location

United States

Related Subject Headings

  • Weight Gain
  • Transaminases
  • Sex Distribution
  • Risk Factors
  • Prospective Studies
  • Proportional Hazards Models
  • Prevalence
  • Middle Aged
  • Male
  • Insulin Resistance
 

Citation

APA
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ICMJE
MLA
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Suzuki, A., Angulo, P., Lymp, J., St Sauver, J., Muto, A., Okada, T., & Lindor, K. (2005). Chronological development of elevated aminotransferases in a nonalcoholic population. Hepatology, 41(1), 64–71. https://doi.org/10.1002/hep.20543
Suzuki, Ayako, Paul Angulo, James Lymp, Jennifer St Sauver, Ayako Muto, Toshihide Okada, and Keith Lindor. “Chronological development of elevated aminotransferases in a nonalcoholic population.Hepatology 41, no. 1 (January 2005): 64–71. https://doi.org/10.1002/hep.20543.
Suzuki A, Angulo P, Lymp J, St Sauver J, Muto A, Okada T, et al. Chronological development of elevated aminotransferases in a nonalcoholic population. Hepatology. 2005 Jan;41(1):64–71.
Suzuki, Ayako, et al. “Chronological development of elevated aminotransferases in a nonalcoholic population.Hepatology, vol. 41, no. 1, Jan. 2005, pp. 64–71. Pubmed, doi:10.1002/hep.20543.
Suzuki A, Angulo P, Lymp J, St Sauver J, Muto A, Okada T, Lindor K. Chronological development of elevated aminotransferases in a nonalcoholic population. Hepatology. 2005 Jan;41(1):64–71.
Journal cover image

Published In

Hepatology

DOI

ISSN

0270-9139

Publication Date

January 2005

Volume

41

Issue

1

Start / End Page

64 / 71

Location

United States

Related Subject Headings

  • Weight Gain
  • Transaminases
  • Sex Distribution
  • Risk Factors
  • Prospective Studies
  • Proportional Hazards Models
  • Prevalence
  • Middle Aged
  • Male
  • Insulin Resistance