Neoadjuvant therapy followed by prostatectomy for clinically localized prostate cancer.

Journal Article (Journal Article;Review)

The results of this assessment of the literature indicated that neoadjuvant therapy followed by prostatectomy may improve long-term outcomes for patients with high-risk localized disease. In addition, this approach provides a paradigm for evaluating the activity and mechanism of action of new agents as correlative studies are facilitated by the availability of tumor tissue before and after therapy. The authors determined that a multidisciplinary approach involving oncologists, urologists, and pathologists is critical to the success of this model. Recent and ongoing studies of neoadjuvant therapy followed by prostatectomy were reviewed.

Full Text

Duke Authors

Cited Authors

  • Sonpavde, G; Chi, KN; Powles, T; Sweeney, CJ; Hahn, N; Hutson, TE; Galsky, MD; Berry, WR; Kadmon, D

Published Date

  • December 15, 2007

Published In

Volume / Issue

  • 110 / 12

Start / End Page

  • 2628 - 2639

PubMed ID

  • 17941029

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/cncr.23085


  • eng

Conference Location

  • United States