Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Published

Journal Article

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.

Full Text

Duke Authors

Cited Authors

  • Bentley, AR; Sung, YJ; Brown, MR; Winkler, TW; Kraja, AT; Ntalla, I; Schwander, K; Chasman, DI; Lim, E; Deng, X; Guo, X; Liu, J; Lu, Y; Cheng, C-Y; Sim, X; Vojinovic, D; Huffman, JE; Musani, SK; Li, C; Feitosa, MF; Richard, MA; Noordam, R; Baker, J; Chen, G; Aschard, H; Bartz, TM; Ding, J; Dorajoo, R; Manning, AK; Rankinen, T; Smith, AV; Tajuddin, SM; Zhao, W; Graff, M; Alver, M; Boissel, M; Chai, JF; Chen, X; Divers, J; Evangelou, E; Gao, C; Goel, A; Hagemeijer, Y; Harris, SE; Hartwig, FP; He, M; Horimoto, ARVR; Hsu, F-C; Hung, Y-J; Jackson, AU; Kasturiratne, A; Komulainen, P; Kühnel, B; Leander, K; Lin, K-H; Luan, J; Lyytikäinen, L-P; Matoba, N; Nolte, IM; Pietzner, M; Prins, B; Riaz, M; Robino, A; Said, MA; Schupf, N; Scott, RA; Sofer, T; Stancáková, A; Takeuchi, F; Tayo, BO; van der Most, PJ; Varga, TV; Wang, T-D; Wang, Y; Ware, EB; Wen, W; Xiang, Y-B; Yanek, LR; Zhang, W; Zhao, JH; Adeyemo, A; Afaq, S; Amin, N; Amini, M; Arking, DE; Arzumanyan, Z; Aung, T; Ballantyne, C; Barr, RG; Bielak, LF; Boerwinkle, E; Bottinger, EP; Broeckel, U; Brown, M; Cade, BE; Campbell, A; Canouil, M; Charumathi, S; Chen, Y-DI; Christensen, K; COGENT-Kidney Consortium, ; Concas, MP; Connell, JM; de Las Fuentes, L; de Silva, HJ; de Vries, PS; Doumatey, A; Duan, Q; Eaton, CB; Eppinga, RN; Faul, JD; Floyd, JS; Forouhi, NG; Forrester, T; Friedlander, Y; Gandin, I; Gao, H; Ghanbari, M; Gharib, SA; Gigante, B; Giulianini, F; Grabe, HJ; Gu, CC; Harris, TB; Heikkinen, S; Heng, C-K; Hirata, M; Hixson, JE; Ikram, MA; EPIC-InterAct Consortium, ; Jia, Y; Joehanes, R; Johnson, C; Jonas, JB; Justice, AE; Katsuya, T; Khor, CC; Kilpeläinen, TO; Koh, W-P; Kolcic, I; Kooperberg, C; Krieger, JE; Kritchevsky, SB; Kubo, M; Kuusisto, J; Lakka, TA; Langefeld, CD; Langenberg, C; Launer, LJ; Lehne, B; Lewis, CE; Li, Y; Liang, J; Lin, S; Liu, C-T; Liu, J; Liu, K; Loh, M; Lohman, KK; Louie, T; Luzzi, A; Mägi, R; Mahajan, A; Manichaikul, AW; McKenzie, CA; Meitinger, T; Metspalu, A; Milaneschi, Y; Milani, L; Mohlke, KL; Momozawa, Y; Morris, AP; Murray, AD; Nalls, MA; Nauck, M; Nelson, CP; North, KE; O'Connell, JR; Palmer, ND; Papanicolau, GJ; Pedersen, NL; Peters, A; Peyser, PA; Polasek, O; Poulter, N; Raitakari, OT; Reiner, AP; Renström, F; Rice, TK; Rich, SS; Robinson, JG; Rose, LM; Rosendaal, FR; Rudan, I; Schmidt, CO; Schreiner, PJ; Scott, WR; Sever, P; Shi, Y; Sidney, S; Sims, M; Smith, JA; Snieder, H; Starr, JM; Strauch, K; Stringham, HM; Tan, NYQ; Tang, H; Taylor, KD; Teo, YY; Tham, YC; Tiemeier, H; Turner, ST; Uitterlinden, AG; Understanding Society Scientific Group, ; van Heemst, D; Waldenberger, M; Wang, H; Wang, L; Wang, L; Wei, WB; Williams, CA; Wilson, G; Wojczynski, MK; Yao, J; Young, K; Yu, C; Yuan, J-M; Zhou, J; Zonderman, AB; Becker, DM; Boehnke, M; Bowden, DW; Chambers, JC; Cooper, RS; de Faire, U; Deary, IJ; Elliott, P; Esko, T; Farrall, M; Franks, PW; Freedman, BI; Froguel, P; Gasparini, P; Gieger, C; Horta, BL; Juang, J-MJ; Kamatani, Y; Kammerer, CM; Kato, N; Kooner, JS; Laakso, M; Laurie, CC; Lee, I-T; Lehtimäki, T; Lifelines Cohort, ; Magnusson, PKE; Oldehinkel, AJ; Penninx, BWJH; Pereira, AC; Rauramaa, R; Redline, S; Samani, NJ; Scott, J; Shu, X-O; van der Harst, P; Wagenknecht, LE; Wang, J-S; Wang, YX; Wareham, NJ; Watkins, H; Weir, DR; Wickremasinghe, AR; Wu, T; Zeggini, E; Zheng, W; Bouchard, C; Evans, MK; Gudnason, V; Kardia, SLR; Liu, Y; Psaty, BM; Ridker, PM; van Dam, RM; Mook-Kanamori, DO; Fornage, M; Province, MA; Kelly, TN; Fox, ER; Hayward, C; van Duijn, CM; Tai, ES; Wong, TY; Loos, RJF; Franceschini, N; Rotter, JI; Zhu, X; Bierut, LJ; Gauderman, WJ; Rice, K; Munroe, PB; Morrison, AC; Rao, DC; Rotimi, CN; Cupples, LA

Published Date

  • April 2019

Published In

Volume / Issue

  • 51 / 4

Start / End Page

  • 636 - 648

PubMed ID

  • 30926973

Pubmed Central ID

  • 30926973

Electronic International Standard Serial Number (EISSN)

  • 1546-1718

Digital Object Identifier (DOI)

  • 10.1038/s41588-019-0378-y

Language

  • eng

Conference Location

  • United States