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Ciprofloxacin. Use as a topical otic preparation.

Publication ,  Journal Article
Brownlee, RE; Hulka, GF; Prazma, J; Pillsbury, HC
Published in: Arch Otolaryngol Head Neck Surg
April 1992

Most common topical otic preparations have been shown to cause sensorineural hearing loss and hair-cell damage in experimental animals. Ciprofloxacin is a relatively new fluoroquinolone with excellent activity against Pseudomonas and methicillin-resistant Staphylococcus aureus. Recent studies have shown oral ciprofloxacin to be effective in the treatment of chronic serous otitis media and malignant external otitis. However, this drug has never been used as a topical otic preparation. Thirty-five albino female guinea pigs were used to investigate the ototoxicity of topical ciprofloxacin hydrochloride. Bilateral transbullae drug delivery tubes were placed and auditory brain-stem response thresholds were recorded at 20, 16, 8, and 4 kHz before treatment and 21 days after the completion of treatment. Two groups of guinea pigs were used. In group 1 (positive controls), five guinea pigs had 0.1 mL of neomycin sulfate administered in one ear while the opposite (control) ear received 0.1 mL of 0.9% sodium chloride solution; in group 2, 30 guinea pigs received 0.75% ciprofloxacin ophthalmic solution and 0.9% sodium chloride solution in the control ear. All drugs were given twice a day for 7 consecutive days. All results were evaluated with paired, two-tailed t test and Hotelling's T2 test, and calculation of power was performed on all nonsignificant results. No significant ototoxic reaction was observed; small increases in hearing thresholds occurred at 4 (5.65 +/- 8.25 dB [mean +/- SD]) and 8 kHz (3.70 +/- 6.63 dB [mean +/- SD]) in the ciprofloxacin-treated ears; however, no significant hair-cell loss was seen.(ABSTRACT TRUNCATED AT 250 WORDS)

Duke Scholars

Published In

Arch Otolaryngol Head Neck Surg

DOI

ISSN

0886-4470

Publication Date

April 1992

Volume

118

Issue

4

Start / End Page

392 / 396

Location

United States

Related Subject Headings

  • Sodium Chloride
  • Otorhinolaryngology
  • Neomycin
  • Hearing Loss, Conductive
  • Hair Cells, Auditory
  • Guinea Pigs
  • Female
  • Evoked Potentials, Auditory, Brain Stem
  • Ear, Inner
  • Ciprofloxacin
 

Citation

APA
Chicago
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Brownlee, R. E., Hulka, G. F., Prazma, J., & Pillsbury, H. C. (1992). Ciprofloxacin. Use as a topical otic preparation. Arch Otolaryngol Head Neck Surg, 118(4), 392–396. https://doi.org/10.1001/archotol.1992.01880040050009
Brownlee, R. E., G. F. Hulka, J. Prazma, and H. C. Pillsbury. “Ciprofloxacin. Use as a topical otic preparation.Arch Otolaryngol Head Neck Surg 118, no. 4 (April 1992): 392–96. https://doi.org/10.1001/archotol.1992.01880040050009.
Brownlee RE, Hulka GF, Prazma J, Pillsbury HC. Ciprofloxacin. Use as a topical otic preparation. Arch Otolaryngol Head Neck Surg. 1992 Apr;118(4):392–6.
Brownlee, R. E., et al. “Ciprofloxacin. Use as a topical otic preparation.Arch Otolaryngol Head Neck Surg, vol. 118, no. 4, Apr. 1992, pp. 392–96. Pubmed, doi:10.1001/archotol.1992.01880040050009.
Brownlee RE, Hulka GF, Prazma J, Pillsbury HC. Ciprofloxacin. Use as a topical otic preparation. Arch Otolaryngol Head Neck Surg. 1992 Apr;118(4):392–396.

Published In

Arch Otolaryngol Head Neck Surg

DOI

ISSN

0886-4470

Publication Date

April 1992

Volume

118

Issue

4

Start / End Page

392 / 396

Location

United States

Related Subject Headings

  • Sodium Chloride
  • Otorhinolaryngology
  • Neomycin
  • Hearing Loss, Conductive
  • Hair Cells, Auditory
  • Guinea Pigs
  • Female
  • Evoked Potentials, Auditory, Brain Stem
  • Ear, Inner
  • Ciprofloxacin