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Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years.

Publication ,  Journal Article
Mao, C; Li, F-R; Yin, Z-X; Lv, Y-B; Luo, J-S; Yuan, J-Q; Mhungu, F; Wang, J-N; Shi, W-Y; Zhou, J-H; Chen, G-C; Gao, X; Kraus, VB; Wu, X-B; Shi, X-M
Published in: J Nutr
June 1, 2019

BACKGROUND: High concentrations of plasma 25-hydroxyvitamin D [25(OH)D], a marker of circulating vitamin D, have been associated with a lower risk of mortality in epidemiologic studies of multiple populations, but the association for Chinese adults aged ≥80 y (oldest old) remains unclear. OBJECTIVE: We investigated the association between plasma [25(OH)D] concentration and all-cause mortality among Chinese adults aged ≥80 y. DESIGN: The present study is a prospective cohort study of 2185 Chinese older adults (median age: 93 y). Prospective all-cause mortality data were analyzed for survival in relation to plasma 25(OH)D using Cox proportional hazards regression models, with adjustments for potential sociodemographic and lifestyle confounders and biomarkers. The associations were measured with HR and 95% CIs. RESULTS: The median plasma 25(OH)D concentration was 34.4 nmol/L at baseline. Over the 5466 person-year follow-up period, 1100 deaths were identified. Men and women were analyzed together as no effect modification by sex was found. After adjusting for multiple potential confounders, the risk of all-cause mortality decreased as the plasma 25(OH)D concentration increased (P-trend <0.01). Compared with the lowest age-specific quartile of plasma 25(OH)D, the adjusted HRs for mortality for the second, third, and fourth age-specific quartiles were 0.72 (95% CI: 0.57, 0.90), 0.73 (95% CI: 0.58, 0.93), and 0.61 (95% CI: 0.47, 0.81), respectively. The observed associations were broadly consistent across age and other subgroups. Sensitivity analyses generated similar results after excluding participants who died within 2 y of follow-up or after further adjustment for ethnicity and chronic diseases. CONCLUSIONS: A higher plasma 25-hydroxyvitamin D concentration was associated with a reduced risk of all-cause mortality among Chinese adults aged ≥80 y. This observed inverse association warrants further investigation in randomized controlled trials testing vitamin D supplementation in this age group.

Duke Scholars

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Published In

J Nutr

DOI

EISSN

1541-6100

Publication Date

June 1, 2019

Volume

149

Issue

6

Start / End Page

1056 / 1064

Location

United States

Related Subject Headings

  • Vitamin D
  • Risk Factors
  • Prospective Studies
  • Proportional Hazards Models
  • Nutrition & Dietetics
  • Mortality
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans
 

Citation

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Mao, C., Li, F.-R., Yin, Z.-X., Lv, Y.-B., Luo, J.-S., Yuan, J.-Q., … Shi, X.-M. (2019). Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years. J Nutr, 149(6), 1056–1064. https://doi.org/10.1093/jn/nxz041
Mao, Chen, Fu-Rong Li, Zhao-Xue Yin, Yue-Bin Lv, Jie-Si Luo, Jin-Qiu Yuan, Florence Mhungu, et al. “Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years.J Nutr 149, no. 6 (June 1, 2019): 1056–64. https://doi.org/10.1093/jn/nxz041.
Mao, Chen, et al. “Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years.J Nutr, vol. 149, no. 6, June 2019, pp. 1056–64. Pubmed, doi:10.1093/jn/nxz041.
Mao C, Li F-R, Yin Z-X, Lv Y-B, Luo J-S, Yuan J-Q, Mhungu F, Wang J-N, Shi W-Y, Zhou J-H, Chen G-C, Gao X, Kraus VB, Wu X-B, Shi X-M. Plasma 25-Hydroxyvitamin D Concentrations Are Inversely Associated with All-Cause Mortality among a Prospective Cohort of Chinese Adults Aged ≥80 Years. J Nutr. 2019 Jun 1;149(6):1056–1064.
Journal cover image

Published In

J Nutr

DOI

EISSN

1541-6100

Publication Date

June 1, 2019

Volume

149

Issue

6

Start / End Page

1056 / 1064

Location

United States

Related Subject Headings

  • Vitamin D
  • Risk Factors
  • Prospective Studies
  • Proportional Hazards Models
  • Nutrition & Dietetics
  • Mortality
  • Male
  • Longitudinal Studies
  • Longevity
  • Humans