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Methodological consensus on clinical proton MRS of the brain: Review and recommendations.

Publication ,  Journal Article
Wilson, M; Andronesi, O; Barker, PB; Bartha, R; Bizzi, A; Bolan, PJ; Brindle, KM; Choi, I-Y; Cudalbu, C; Dydak, U; Emir, UE; Gonzalez, RG ...
Published in: Magn Reson Med
August 2019

Proton MRS (1 H MRS) provides noninvasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Although most modern clinical MR scanners support MRS capabilities, routine use is largely restricted to specialized centers with good access to MR research support. Widespread adoption has been slow for several reasons, and technical challenges toward obtaining reliable good-quality results have been identified as a contributing factor. Considerable progress has been made by the research community to address many of these challenges, and in this paper a consensus is presented on deficiencies in widely available MRS methodology and validated improvements that are currently in routine use at several clinical research institutions. In particular, the localization error for the PRESS localization sequence was found to be unacceptably high at 3 T, and use of the semi-adiabatic localization by adiabatic selective refocusing sequence is a recommended solution. Incorporation of simulated metabolite basis sets into analysis routines is recommended for reliably capturing the full spectral detail available from short TE acquisitions. In addition, the importance of achieving a highly homogenous static magnetic field (B0 ) in the acquisition region is emphasized, and the limitations of current methods and hardware are discussed. Most recommendations require only software improvements, greatly enhancing the capabilities of clinical MRS on existing hardware. Implementation of these recommendations should strengthen current clinical applications and advance progress toward developing and validating new MRS biomarkers for clinical use.

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Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

August 2019

Volume

82

Issue

2

Start / End Page

527 / 550

Location

United States

Related Subject Headings

  • Protons
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Humans
  • Consensus
  • Brain
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
 

Citation

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Wilson, M., Andronesi, O., Barker, P. B., Bartha, R., Bizzi, A., Bolan, P. J., … Howe, F. A. (2019). Methodological consensus on clinical proton MRS of the brain: Review and recommendations. Magn Reson Med, 82(2), 527–550. https://doi.org/10.1002/mrm.27742
Wilson, Martin, Ovidiu Andronesi, Peter B. Barker, Robert Bartha, Alberto Bizzi, Patrick J. Bolan, Kevin M. Brindle, et al. “Methodological consensus on clinical proton MRS of the brain: Review and recommendations.Magn Reson Med 82, no. 2 (August 2019): 527–50. https://doi.org/10.1002/mrm.27742.
Wilson M, Andronesi O, Barker PB, Bartha R, Bizzi A, Bolan PJ, et al. Methodological consensus on clinical proton MRS of the brain: Review and recommendations. Magn Reson Med. 2019 Aug;82(2):527–50.
Wilson, Martin, et al. “Methodological consensus on clinical proton MRS of the brain: Review and recommendations.Magn Reson Med, vol. 82, no. 2, Aug. 2019, pp. 527–50. Pubmed, doi:10.1002/mrm.27742.
Wilson M, Andronesi O, Barker PB, Bartha R, Bizzi A, Bolan PJ, Brindle KM, Choi I-Y, Cudalbu C, Dydak U, Emir UE, Gonzalez RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Huppi PS, Hurd RE, Kantarci K, Kauppinen RA, Klomp DWJ, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjańska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Mullins PG, Murdoch JB, Nelson SJ, Noeske R, Öz G, Pan JW, Peet AC, Poptani H, Posse S, Ratai E-M, Salibi N, Scheenen TWJ, Smith ICP, Soher BJ, Tkáč I, Vigneron DB, Howe FA. Methodological consensus on clinical proton MRS of the brain: Review and recommendations. Magn Reson Med. 2019 Aug;82(2):527–550.
Journal cover image

Published In

Magn Reson Med

DOI

EISSN

1522-2594

Publication Date

August 2019

Volume

82

Issue

2

Start / End Page

527 / 550

Location

United States

Related Subject Headings

  • Protons
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Humans
  • Consensus
  • Brain
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering