Antimullerian hormone and obesity: insights in oral contraceptive users.

Published

Journal Article

BACKGROUND: The study was conducted to examine the impact of oral contraceptives (OCs) on serum antimullerian hormone (AMH) levels by obesity status in reproductive-age women. STUDY DESIGN: Ovulatory women, ages 18-35 years, of normal (<25 kg/m(2); n=10) and obese (>30 kg/m(2); n=10) body mass index (BMI) received a low-dose OC (20 mcg ethinyl estradiol/100 mcg levonorgestrel) for two cycles. Serum samples obtained at several time points during active pill use and hormone-free intervals were analyzed for AMH, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol and inhibin B. RESULTS: AMH levels did not differ by OC cycle day in either BMI group. On average, AMH levels were 34% lower in the obese group (2.9+/-2.1 vs. 4.4+/-1.8 ng/mL, p<.05). Modeling to determine differences in AMH throughout the cycle based on obesity status demonstrated significantly lower levels (p<.05), whereas serum AMH, FSH, LH, estradiol and inhibin B levels revealed no correlations when all time points were included. CONCLUSIONS: In reproductive-age women, serum AMH levels do not appear to fluctuate during OC use, but AMH levels are significantly lower in obese women. Lower levels do not appear to be due to differences in gonadotropin levels or ovarian activity.

Full Text

Duke Authors

Cited Authors

  • Steiner, AZ; Stanczyk, FZ; Patel, S; Edelman, A

Published Date

  • March 2010

Published In

Volume / Issue

  • 81 / 3

Start / End Page

  • 245 - 248

PubMed ID

  • 20159182

Pubmed Central ID

  • 20159182

Electronic International Standard Serial Number (EISSN)

  • 1879-0518

Digital Object Identifier (DOI)

  • 10.1016/j.contraception.2009.10.004

Language

  • eng

Conference Location

  • United States