Effects of perfluorinated chemicals on thyroid function, markers of ovarian reserve, and natural fertility.

Journal Article (Journal Article)

Perfluorinated chemicals (PFCs) can act as endocrine-disrupting chemicals, but there has been limited study of their effects on ovarian reserve or fecundability. 99 women, 30-44 years old, without infertility were followed until pregnancy. Initially, serum was evaluated for Antimullerian hormone (AMH), thyroid hormones: thyroid stimulating hormone (TSH), thyroxine (T4), free thyroxine (fT4), and triiodothyronine (T3), and PFCs: perfluorooctanoate (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexanesulfonic acid (PFHxS). Bivariate analyses assessed the relationship between thyroid hormones, AMH, and PFCs. Fecundability ratios (FR) were determined for each PFC using a discrete time-varying Cox model and a day-specific probability model. PFC levels were positively correlated with each other (r 0.24-0.90), but there was no correlation with TSH (r 0.02-0.15) or AMH (r -0.01 to -0.15). FR point estimates for each PFC were neither strong nor statistically significant. Although increased exposure to PFCs correlates with thyroid hormone levels, there is no significant association with fecundability or ovarian reserve.

Full Text

Duke Authors

Cited Authors

  • Crawford, NM; Fenton, SE; Strynar, M; Hines, EP; Pritchard, DA; Steiner, AZ

Published Date

  • April 2017

Published In

Volume / Issue

  • 69 /

Start / End Page

  • 53 - 59

PubMed ID

  • 28111093

Pubmed Central ID

  • PMC5690561

Electronic International Standard Serial Number (EISSN)

  • 1873-1708

Digital Object Identifier (DOI)

  • 10.1016/j.reprotox.2017.01.006


  • eng

Conference Location

  • United States