Skip to main content
Journal cover image

Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women.

Publication ,  Journal Article
Seungdamrong, A; Steiner, AZ; Gracia, CR; Legro, RS; Diamond, MP; Coutifaris, C; Schlaff, WD; Casson, P; Christman, GM; Robinson, RD; Huang, H ...
Published in: Fertility and sterility
October 2017

To study whether preconceptual thyroid-stimulating hormone (TSH) and antithyroid peroxidase (TPO) antibodies are associated with poor reproductive outcomes in infertile women.Secondary analysis of data from two multicenter, randomized, controlled trials conducted by the Reproductive Medicine Network of the Eunice Kennedy Shriver National Institute of Child Health and Human Development. Multivariable logistic regression analyses were performed to assess the association between preconceptual TSH levels and anti-TPO antibodies.Not applicable.Serum samples from 1,468 infertile women were utilized.None.Cumulative conception, clinical pregnancy, miscarriage, and live birth rates were calculated.Conception, clinical pregnancy, miscarriage, and live birth rates did not differ between patients with TSH ≥2.5 mIU/L vs. TSH < 2.5 mIU/L. Women with anti-TPO antibodies had similar conception rates (33.3% vs. 36.3%) but higher miscarriage rates (43.9% vs. 25.3%) and lower live birth rates (17.1% vs. 25.4%) than those without anti-TPO antibodies. Adjusted, multivariable logistic regression models confirmed elevated odds of miscarriage (odds ratio 2.17, 95% confidence interval 1.12-4.22) and lower odds of live birth (oddr ratio 0.58, 95% confidence interval 0.35-0.96) in patients with anti-TPO antibodies.In infertile women, preconceptional TSH ≥2.5 mIU/L is not associated with adverse reproductive outcomes; however, anti-TPO antibodies are associated with increased risk of miscarriage and decreased probability of live birth.PPCOS II NCT00719186; AMIGOS NCT01044862.

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Fertility and sterility

DOI

EISSN

1556-5653

ISSN

0015-0282

Publication Date

October 2017

Start / End Page

S0015-0282(17)31748-X

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • 3215 Reproductive medicine
  • 1117 Public Health and Health Services
  • 1114 Paediatrics and Reproductive Medicine
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Seungdamrong, A., Steiner, A. Z., Gracia, C. R., Legro, R. S., Diamond, M. P., Coutifaris, C., … Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network, . (2017). Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women. Fertility and Sterility, S0015-0282(17)31748-X. https://doi.org/10.1016/j.fertnstert.2017.08.026
Seungdamrong, Aimee, Anne Z. Steiner, Clarisa R. Gracia, Richard S. Legro, Michael P. Diamond, Christos Coutifaris, William D. Schlaff, et al. “Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women.Fertility and Sterility, October 2017, S0015-0282(17)31748-X. https://doi.org/10.1016/j.fertnstert.2017.08.026.
Seungdamrong A, Steiner AZ, Gracia CR, Legro RS, Diamond MP, Coutifaris C, et al. Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women. Fertility and sterility. 2017 Oct;S0015-0282(17)31748-X.
Seungdamrong, Aimee, et al. “Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women.Fertility and Sterility, Oct. 2017, pp. S0015-0282(17)31748-X. Epmc, doi:10.1016/j.fertnstert.2017.08.026.
Seungdamrong A, Steiner AZ, Gracia CR, Legro RS, Diamond MP, Coutifaris C, Schlaff WD, Casson P, Christman GM, Robinson RD, Huang H, Alvero R, Hansen KR, Jin S, Eisenberg E, Zhang H, Santoro N, Eunice Kennedy Shriver National Institute of Child Health and Human Development Reproductive Medicine Network. Preconceptional antithyroid peroxidase antibodies, but not thyroid-stimulating hormone, are associated with decreased live birth rates in infertile women. Fertility and sterility. 2017 Oct;S0015-0282(17)31748-X.
Journal cover image

Published In

Fertility and sterility

DOI

EISSN

1556-5653

ISSN

0015-0282

Publication Date

October 2017

Start / End Page

S0015-0282(17)31748-X

Related Subject Headings

  • Obstetrics & Reproductive Medicine
  • 3215 Reproductive medicine
  • 1117 Public Health and Health Services
  • 1114 Paediatrics and Reproductive Medicine
  • 1103 Clinical Sciences