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Association between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination population.

Publication ,  Journal Article
Trussell, JC; Coward, RM; Santoro, N; Stetter, C; Kunselman, A; Diamond, MP; Hansen, KR; Krawetz, SA; Legro, RS; Heisenleder, D; Smith, J ...
Published in: Fertility and sterility
June 2019

To determine whether men with unexplained infertility and low total T (TT) have abnormal spermatogenesis and lower fecundity.Secondary analysis of the prospective, randomized, multicenter clinical trial, Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS).Infertility clinics.Nine hundred couples with unexplained infertility enrolled in AMIGOS. Semen analysis with an ejaculate of at least 5 million total motile sperm was required for enrollment. For inclusion in this secondary analysis, a fasting TT was required.None.Logistic regression, adjusted for age and body mass index, assessed the association between low TT (defined as <264 ng/dL), semen parameters, and pregnancy outcome.Seven hundred eighty-one men (mean age, 34.2 ± 5.7 years) with a median (interquartile range) TT of 411 (318-520) ng/dL were included. Men with TT <264 ng/dL were less likely to have normal (≥4% strict Kruger) morphology (unadjusted odds ratio [OR], 0.56; 95% confidence interval [CI], 0.34, 0.92; adjusted OR, 0.59; 95% CI, 0.35, 0.99). There was no association between low TT and semen volume < 1.5 mL, sperm concentration < 15 × 106/mL, or motility < 40%. Among couples whose male partner had low TT, 21 (18.8%) had a live birth, compared with 184 (27.5%) live births in couples with a male partner having TT > 264 ng/dL. The odds of live birth decreased by 40% in couples whose male partner had low TT (unadjusted OR, 0.60; 95% CI, 0.36, 1.00; adjusted OR, 0.65; 95% CI, 0.38, 1.12).In couples with unexplained infertility, low TT in the male partner was associated with abnormal sperm morphology and lower live birth rates.NCT01044862.

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Published In

Fertility and sterility

DOI

EISSN

1556-5653

ISSN

0015-0282

Publication Date

June 2019

Volume

111

Issue

6

Start / End Page

1129 / 1134

Related Subject Headings

  • Treatment Outcome
  • Testosterone
  • Spermatogenesis
  • Sperm Motility
  • Sperm Count
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Pregnancy Rate
  • Pregnancy
  • Obstetrics & Reproductive Medicine
 

Citation

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Trussell, J. C., Coward, R. M., Santoro, N., Stetter, C., Kunselman, A., Diamond, M. P., … Reproductive Medicine Network, . (2019). Association between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination population. Fertility and Sterility, 111(6), 1129–1134. https://doi.org/10.1016/j.fertnstert.2019.01.034
Trussell, J. C., R Matthew Coward, Nanette Santoro, Christy Stetter, Allen Kunselman, Michael P. Diamond, Karl R. Hansen, et al. “Association between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination population.Fertility and Sterility 111, no. 6 (June 2019): 1129–34. https://doi.org/10.1016/j.fertnstert.2019.01.034.
Trussell JC, Coward RM, Santoro N, Stetter C, Kunselman A, Diamond MP, et al. Association between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination population. Fertility and sterility. 2019 Jun;111(6):1129–34.
Trussell, J. C., et al. “Association between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination population.Fertility and Sterility, vol. 111, no. 6, June 2019, pp. 1129–34. Epmc, doi:10.1016/j.fertnstert.2019.01.034.
Trussell JC, Coward RM, Santoro N, Stetter C, Kunselman A, Diamond MP, Hansen KR, Krawetz SA, Legro RS, Heisenleder D, Smith J, Steiner A, Wild R, Casson P, Coutifaris C, Alvero RR, Robinson RB, Christman G, Patrizio P, Zhang H, Lindgren MC, Reproductive Medicine Network. Association between testosterone, semen parameters, and live birth in men with unexplained infertility in an intrauterine insemination population. Fertility and sterility. 2019 Jun;111(6):1129–1134.
Journal cover image

Published In

Fertility and sterility

DOI

EISSN

1556-5653

ISSN

0015-0282

Publication Date

June 2019

Volume

111

Issue

6

Start / End Page

1129 / 1134

Related Subject Headings

  • Treatment Outcome
  • Testosterone
  • Spermatogenesis
  • Sperm Motility
  • Sperm Count
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Pregnancy Rate
  • Pregnancy
  • Obstetrics & Reproductive Medicine