Evidence of transcranial direct current stimulation-generated electric fields at subthalamic level in human brain in vivo.

Published

Journal Article

BACKGROUND:Transcranial direct current stimulation (tDCS) is a promising brain modulation technique for several disease conditions. With this technique, some portion of the current penetrates through the scalp to the cortex and modulates cortical excitability, but a recent human cadaver study questions the amount. This insufficient intracerebral penetration of currents may partially explain the inconsistent and mixed results in tDCS studies to date. Experimental validation of a transcranial alternating current stimulation-generated electric field (EF) in vivo has been performed on the cortical (using electrocorticography, ECoG, electrodes), subcortical (using stereo electroencephalography, SEEG, electrodes) and deeper thalamic/subthalamic levels (using DBS electrodes). However, tDCS-generated EF measurements have never been attempted. OBJECTIVE:We aimed to demonstrate that tDCS generates biologically relevant EF as deep as the subthalamic level in vivo. METHODS:Patients with movement disorders who have implanted deep brain stimulation (DBS) electrodes serve as a natural experimental model for thalamic/subthalamic recordings of tDCS-generated EF. We measured voltage changes from DBS electrodes and body resistance from tDCS electrodes in three subjects while applying direct current to the scalp at 2 mA and 4 mA over two tDCS montages. RESULTS:Voltage changes at the level of deep nuclei changed proportionally with the level of applied current and varied with different tDCS montages. CONCLUSIONS:Our findings suggest that scalp-applied tDCS generates biologically relevant EF. Incorporation of these experimental results may improve finite element analysis (FEA)-based models.

Full Text

Duke Authors

Cited Authors

  • Chhatbar, PY; Kautz, SA; Takacs, I; Rowland, NC; Revuelta, GJ; George, MS; Bikson, M; Feng, W

Published Date

  • July 2018

Published In

Volume / Issue

  • 11 / 4

Start / End Page

  • 727 - 733

PubMed ID

  • 29576498

Pubmed Central ID

  • 29576498

Electronic International Standard Serial Number (EISSN)

  • 1876-4754

International Standard Serial Number (ISSN)

  • 1935-861X

Digital Object Identifier (DOI)

  • 10.1016/j.brs.2018.03.006

Language

  • eng